Integrin subunit beta 3 (Q4201964)

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mammalian protein found in Homo sapiens
  • platelet membrane glycoprotein IIIa
  • integrin beta-3
  • ITGB3
  • antigen CD61
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • GPIIIa
  • integrin beta 3
  • integrin beta chain, beta 3
edit
Language Label Description Also known as
English
Integrin subunit beta 3
mammalian protein found in Homo sapiens
  • platelet membrane glycoprotein IIIa
  • integrin beta-3
  • ITGB3
  • antigen CD61
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • GPIIIa
  • integrin beta 3
  • integrin beta chain, beta 3

Statements

molecular function
protein binding
determination method
IPI
37 references
retrieved
9 May 2019
stated in
A role for the thiol isomerase protein ERP5 in platelet function
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structure of the integrin binding fragment from fibrillin-1 gives new insights into microfibril organization
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
CCN3 (NOV) Is a Novel Angiogenic Regulator of the CCN Protein Family
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structure of an integrin  IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structural mechanism of integrin inactivation by filamin.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
TA205, an anti-talin monoclonal antibody, inhibits integrin-talin interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis of integrin activation by talin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structural diversity in integrin/talin interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Crystal structure of the extracellular segment of integrin alpha Vbeta3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Src kinase activation by direct interaction with the integrin β cytoplasmic domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Basic amino-acid side chains regulate transmembrane integrin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
A novel adaptation of the integrin PSI domain revealed from its crystal structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
PTP-1B is an essential positive regulator of platelet integrin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
An interaction between alpha-actinin and the beta 1 integrin subunit in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Quantifying the specific binding between West Nile virus envelope domain III protein and the cellular receptor alphaVbeta3 integrin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Structural determinants of integrin recognition by talin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
retrieved
9 May 2019
stated in
Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IPI
cell component
cell surface
determination method
IDA
9 references
retrieved
17 October 2017
stated in
Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
17 October 2017
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05106&geneProductId=UniProtKB:P05106
determination method
IDA
integrin alphav-beta3 complex
determination method
IDA
5 references
retrieved
9 May 2019
stated in
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
cell surface
determination method
HDA
IBA
IDA
10 references
retrieved
9 May 2019
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Characterization of integrin engagement during defined human embryonic stem cell culture
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
IBA
retrieved
9 May 2019
stated in
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
HDA
retrieved
9 May 2019
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P05106
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05106
determination method
HDA
biological process
Gene Atlas image
PBB GE ITGB3 204628 s at fs.png
732 × 530; 12 KB
0 references
Commons category
Integrin beta-3
0 references

Identifiers

Freebase ID
/m/02qzskc
0 references
PDB structure ID
 
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                Retrieved from "https://www.wikidata.org/w/index.php?title=Q4201964&oldid=2022905177"