A Pin1/mutant p53 axis promotes aggressiveness in breast cancer (Q24312083)

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7 February 2020

title

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer (English)

1 reference

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Transformation related protein 53

7 February 2020

main subject

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Peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1

GOA release 2020-03-11

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GOA release 2020-03-11

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2

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Silvano Piazza

3

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7 February 2020

Philip R Quinlan

9

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7 February 2020

Miguel Mano

11

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7 February 2020

Antonio Rosato

12

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7 February 2020

Eugenio Scanziani

14

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7 February 2020

Giannino Del Sal

18

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7 February 2020

17

Claudio Schneider

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7 February 2020

author name string

Javier E Girardini

1

1 reference

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7 February 2020

Alessandra Rustighi

4

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7 February 2020

Carolina Marotta

5

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7 February 2020

Enrico Radaelli

6

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7 February 2020

Valeria Capaci

7

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7 February 2020

Lee Jordan

8

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7 February 2020

Alastair Thompson

10

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7 February 2020

Tim Crook

13

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7 February 2020

Anthony R Means

15

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7 February 2020

Guillermina Lozano

16

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7 February 2020

language of work or name

English

0 references

publication date

1 July 2011

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7 February 2020

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7 February 2020

volume

20

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issue

1

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7 February 2020

page(s)

79-91

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The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1.

7 February 2020

cites work

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7 January 2021

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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7 January 2021

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

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7 January 2021

Shaping genetic alterations in human cancer: the p53 mutation paradigm

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

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Mutant p53 drives invasion by promoting integrin recycling

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7 January 2021

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

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7 January 2021

Prevalent overexpression of prolyl isomerase Pin1 in human cancers

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Assessing TP53 status in human tumours to evaluate clinical outcome

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Gene expression profiling predicts clinical outcome of breast cancer

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7 January 2021

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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7 January 2021

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

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7 January 2021

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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7 January 2021

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

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7 January 2021

PIN1, the cell cycle and cancer.

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7 January 2021

When mutants gain new powers: news from the mutant p53 field.

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7 January 2021

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

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7 January 2021

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

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7 January 2021

TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells.

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7 January 2021

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

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7 January 2021

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

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Involvement of upregulation of DEPDC1 (DEP domain containing 1) in bladder carcinogenesis

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7 January 2021

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

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7 January 2021

Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis

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7 January 2021

Mutant p53 gain-of-function in cancer

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7 January 2021

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

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7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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7 January 2021

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

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7 January 2021

15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer

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7 January 2021

Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells

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7 January 2021

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

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7 January 2021

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

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7 January 2021

An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

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7 January 2021

MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression

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7 January 2021

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

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7 January 2021

TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

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7 January 2021

Pin1 regulates the timing of mammalian primordial germ cell proliferation

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Novel snail1 target proteins in human colon cancer identified by proteomic analysis

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Caveolin-1 in breast cancer

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