A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity (Q24312181)

RTF1 homolog, Paf1/RNA polymerase II complex component

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CTR9 homolog, Paf1/RNA polymerase II complex component

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stem cell population maintenance

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Leo1, Paf1/RNA polymerase II complex component

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CTR9 homolog, Paf1/RNA polymerase II complex component

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RTF1, Paf1/RNA polymerase II complex component

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Paf1, RNA polymerase II complex component

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Cell division cycle 73, Paf1/RNA polymerase II complex component

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22

Frank Buchholz

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Agapios Sachinidis

13

object named as

Agapios Sachinidis

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Ina Poser

20

object named as

Ina Poser

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author name string

Li Ding

1

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Maciej Paszkowski-Rogacz

2

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Anja Nitzsche

3

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Mikolaj Michal Slabicki

4

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Anne-Kristin Heninger

5

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Ingrid de Vries

6

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Ralf Kittler

7

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Magno Junqueira

8

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Andrej Shevchenko

9

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Herbert Schulz

10

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Norbert Hubner

11

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Michael Xavier Doss

12

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Juergen Hescheler

14

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Roberto Iacone

15

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Konstantinos Anastassiadis

16

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A Francis Stewart

17

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M Teresa Pisabarro

18

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Antonio Caldarelli

19

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Mirko Theis

Directing pluripotent cell differentiation using "diced RNA" in transient transfection

21

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language of work or name

English

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publication date

8 May 2009

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published in

Cell Stem Cell

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volume

4

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issue

5

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page(s)

403-15

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cites work

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Stem cell regulation by polycomb repressors: postponing commitment

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Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

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Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

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Capturing pluripotency

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An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.

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A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.

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Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation

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Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

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Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

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A predictable ligand regulated expression strategy for stably integrated transgenes in mammalian cells in culture.

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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

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Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

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An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

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Dissecting self-renewal in stem cells with RNA interference

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Changing potency by spontaneous fusion.

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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

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Genome-scale RNAi profiling of cell division in human tissue culture cells

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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

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Production of endoribonuclease-prepared short interfering RNAs for gene silencing in mammalian cells

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BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

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Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation

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Self-renewal of teratocarcinoma and embryonic stem cells.

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Optimization and integration of expansion and neural commitment of mouse embryonic stem cells.

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Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells

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RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells

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Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling

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Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice.

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Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression.

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The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.

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CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex

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Self-renewal vs. differentiation of mouse embryonic stem cells

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The human PAF complex coordinates transcription with events downstream of RNA synthesis

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Embryonic stem cell differentiation: emergence of a new era in biology and medicine

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Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice

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Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme

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Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae

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Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

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Drosophila Paf1 modulates chromatin structure at actively transcribed genes.

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Mediator of Transcriptional Regulation

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Oct-4: gatekeeper in the beginnings of mammalian development.

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Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells

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