Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab (Q24313194)

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English	Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab	scientific article

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Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab (English)

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ADAM metallopeptidase domain 17

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GOA release 2020-03-11

transforming growth factor beta receptor 1

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GOA release 2020-03-11

transforming growth factor beta 1

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GOA release 2020-03-11

A disintegrin and metallopeptidase domain 17

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GOA release 2020-03-11

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based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Atanasio Pandiella

7

object named as

Atanasio Pandiella

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Carlos L Arteaga

8

object named as

Carlos L Arteaga

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author name string

Shizhen Emily Wang

1

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Bin Xiang

2

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Marta Guix

3

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Maria Graciela Olivares

4

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Joel Parker

5

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Christine H Chung

6

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language of work or name

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publication date

September 2008

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Molecular and Cellular Biology

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28

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18

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5605-20

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HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors

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The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

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Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

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Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

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A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

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19 March 2017

TGF-beta signal transduction

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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Untangling the ErbB signalling network

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Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

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HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta

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ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking

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Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility

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