Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins (Q24316283)

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Julien Laboureau

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Alain Mauviel

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Kunxin Luo

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

30 August 2005

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published in

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volume

102

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issue

35

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page(s)

12437-42

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cites work

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Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling

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Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN

19 March 2017

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Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

19 March 2017

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The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

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Isolation of human cDNA clones of ski and the ski-related gene, sno

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

19 March 2017

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Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: functional implications for transforming growth factor beta signaling

22 April 2017

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SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus

19 March 2017

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

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c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

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SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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Inability of transforming growth factor-beta to cause SnoN degradation leads to resistance to transforming growth factor-beta-induced growth arrest in esophageal cancer cells

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Ski and SnoN: negative regulators of TGF-beta signaling

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The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction

27 September 2017

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Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract

27 September 2017

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Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins

27 September 2017

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Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

27 September 2017

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The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

27 September 2017

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Proteasomal activity modulates TGF-ss signaling in a gene-specific manner

30 May 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0504107102

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0504107102

Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0504107102

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16109768

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0504107102

1 reference

ADS bibcode

2005PNAS..10212437K

0 references

1 reference

1 reference

PubMed publication ID

16109768

1 reference