Identification of PP2A complexes and pathways involved in cell transformation (Q24316472)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21159657%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Identification of PP2A complexes and pathways involved in cell transformation (English)

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18 January 2020

1

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18 January 2020

4

William C Hahn

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18 January 2020

author name string

Melissa Hector

series ordinal

2

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18 January 2020

Nathalie Colpaert

series ordinal

3

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18 January 2020

language of work or name

English

0 references

publication date

1 December 2010

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18 January 2020

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18 January 2020

volume

70

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18 January 2020

issue

24

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18 January 2020

page(s)

10474-10484

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PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

18 January 2020

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Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

19 March 2017

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Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis

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19 March 2017

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19 March 2017

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Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16

19 March 2017

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Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers

19 March 2017

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19 March 2017

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

19 March 2017

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19 March 2017

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

19 March 2017

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Structural Basis of PP2A Inhibition by Small t Antigen

19 March 2017

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Generation of active protein phosphatase 2A is coupled to holoenzyme assembly

19 March 2017

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Identification of specific PP2A complexes involved in human cell transformation

19 March 2017

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A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.

19 March 2017

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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

19 March 2017

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Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene

19 March 2017

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Creation of human tumour cells with defined genetic elements

19 March 2017

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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

19 March 2017

1 reference

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Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

19 March 2017

1 reference

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Alterations of the PPP2R1B gene in human lung and colon cancer

19 March 2017

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alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

19 March 2017

1 reference

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Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

19 March 2017

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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

19 March 2017

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Protein phosphatase 2A regulatory subunits and cancer.

7 April 2017

1 reference

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A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins

27 September 2017

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Integrative genomic approaches identify IKBKE as a breast cancer oncogene

27 September 2017

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The 3D structure of protein phosphatase 2A: new insights into a ubiquitous regulator of cell signaling

27 September 2017

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Functional genetics and experimental models of human cancer

27 September 2017

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

27 September 2017

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Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells

27 September 2017

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Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

27 September 2017

1 reference

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

27 September 2017

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Critical role for SV40 small-t antigen in human cell transformation

27 September 2017

1 reference

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Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen

27 September 2017

1 reference

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

27 September 2017

1 reference

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Ras enhances Myc protein stability.

27 September 2017

1 reference

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Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056544

Risky immortalization by telomerase

29 November 2018

1 reference

12 December 2020

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms

1 reference

12 December 2020

Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity

1 reference

12 December 2020

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

1 reference

12 December 2020

10.1158/0008-5472.CAN-10-2855

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18 January 2020

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18 January 2020

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