Janus kinase 2 (Q3162114)

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mammalian protein found in Homo sapiens
  • tyrosine-protein kinase JAK2
  • JAK-2
  • Janus kinase 2 (a protein tyrosine kinase)
  • JAK2
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Language Label Description Also known as
English
Janus kinase 2
mammalian protein found in Homo sapiens
  • tyrosine-protein kinase JAK2
  • JAK-2
  • Janus kinase 2 (a protein tyrosine kinase)
  • JAK2

Statements

part of
molecular function
protein binding
determination method
IPI
14 references
retrieved
9 May 2019
stated in
Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response
GOA
curator
UniProt
UniProt protein ID
O60674
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
hTid-1, a human DnaJ protein, modulates the interferon signaling pathway
GOA
curator
UniProt
UniProt protein ID
O60674
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development
GOA
curator
UniProt
UniProt protein ID
O60674
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
PTP1B regulates leptin signal transduction in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
Mpl traffics to the cell surface through conventional and unconventional routes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
retrieved
9 May 2019
stated in
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IPI
protein tyrosine kinase activity
determination method
EXP
IDA
ISS
TAS
IEA
11 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
TAS
retrieved
9 May 2019
stated in
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60674
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O60674
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IEA
retrieved
9 May 2019
stated in
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
IDA
retrieved
9 May 2019
stated in
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
EXP
retrieved
9 May 2019
stated in
Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
EXP
retrieved
9 May 2019
stated in
Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
EXP
retrieved
9 May 2019
stated in
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674
determination method
EXP
cell component
biological process
physically interacts with
has part(s)

Identifiers

MeSH descriptor ID
D053614
subject named as
Janus Kinase 2
0 references
PDB structure ID
 
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