MOZ increases p53 acetylation and premature senescence through its complex formation with PML (Q24319117)

Lysine acetyltransferase 6A

1 reference

PML nuclear body scaffold

1 reference

cellular senescence

1 reference

6

Carol Prives

0 references

author name string

Susumu Rokudai

1

0 references

Oleg Laptenko

2

0 references

Suzzette M Arnal

3

0 references

Yoichi Taya

4

0 references

Issay Kitabayashi

Proceedings of the National Academy of Sciences of the United States of America

5

0 references

language of work or name

English

0 references

publication date

5 March 2013

0 references

published in

0 references

volume

110

0 references

page(s)

3895-900

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issue

10

0 references

cites work

Acetylation is indispensable for p53 activation

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hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

19 March 2017

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ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

19 March 2017

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Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein

19 March 2017

1 reference

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

19 March 2017

1 reference

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

19 March 2017

1 reference

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

19 March 2017

1 reference

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Role of SUMO-1-modified PML in nuclear body formation

19 March 2017

1 reference

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

19 March 2017

1 reference

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

19 March 2017

1 reference

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The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

19 March 2017

1 reference

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The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

19 March 2017

1 reference

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Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

19 March 2017

1 reference

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

19 March 2017

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19 March 2017

Surfing the p53 network

1 reference

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

The function of PML in p53-dependent apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300

19 March 2017

1 reference

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

MOZ is essential for maintenance of hematopoietic stem cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Blinded by the Light: The Growing Complexity of p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Live or let die: the cell's response to p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

The p53 pathway: positive and negative feedback loops

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

PML3 Orchestrates the Nuclear Dynamics and Function of TIP60

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Identification of a tumour suppressor network opposing nuclear Akt function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Transcriptional regulation by p53: one protein, many possibilities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

The p53 and Mdm2 families in cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

PML is induced by oncogenic ras and promotes premature senescence

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593914

Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1300490110

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1300490110

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23431171

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23431171

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1300490110

0 references

ADS bibcode

2013PNAS..110.3895R

0 references

Fatcat ID

release_gbk3o3nukbdmpoplxlkajw4emm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gbk3o3nukbdmpoplxlkajw4emm