p53 mediates the negative regulation of MDM2 by orphan receptor TR3 (Q24321873)

1

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Hang-zi Chen

2

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Na-zi Lei

3

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Gui-deng Li

4

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Wen-xiu Zhao

5

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Yan-yan Zhan

6

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Bo Liu

7

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Sheng-cai Lin

8

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Qiao Wu

Negative regulation of p53 functions by Daxx and the involvement of MDM2

9

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language of work or name

English

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publication date

13 December 2006

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published in

The EMBO Journal

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volume

25

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issue

24

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page(s)

5703-15

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cites work

1 reference

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

19 March 2017

1 reference

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Binding and modulation of p53 by p300/CBP coactivators

19 March 2017

1 reference

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Synergistic activation of transcription by CBP and p53

19 March 2017

1 reference

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Mdm2 promotes the rapid degradation of p53

19 March 2017

1 reference

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Identification of a new member of the steroid receptor super-family by cloning and sequence analysis

19 March 2017

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19 March 2017

Surfing the p53 network

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Regulation of p53 stability by Mdm2

6 April 2017

1 reference

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Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

19 March 2017

1 reference

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MDM2--master regulator of the p53 tumor suppressor protein

19 March 2017

1 reference

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation

19 March 2017

1 reference

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Recruitment of p300/CBP in p53-dependent signal pathways

19 March 2017

1 reference

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

19 March 2017

1 reference

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Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

19 March 2017

1 reference

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The RXR heterodimers and orphan receptors

19 March 2017

1 reference

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mdm2 expression is induced by wild type p53 activity

7 April 2017

1 reference

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HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

7 April 2017

1 reference

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MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

27 September 2017

1 reference

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The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage

27 September 2017

1 reference

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RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

The transcriptional repressor hDaxx potentiates p53-dependent apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Yin Yang 1 is a negative regulator of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells

27 September 2017

1 reference

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Decision making by p53: life, death and cancer

27 September 2017

1 reference

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Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Control of p53 ubiquitination and nuclear export by MDM2 and ARF.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Mechanisms of switching on p53: a role for covalent modification?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Database of p53 gene somatic mutations in human tumors and cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

TR3/Nur77 in colon cancer cell apoptosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4‐HPR

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1698882

p53 Mutation and MDM2 amplification in human soft tissue sarcomas

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17139261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role for p300 in stabilization of p53 in the response to DNA damage

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17139261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601435

1 reference

2027336

2027336

1 reference

1 reference

1 reference