OTUB1 modulates c-IAP1 stability to regulate signalling pathways (Q24337266)

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27 February 2020

title

OTUB1 modulates c-IAP1 stability to regulate signalling pathways (English)

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27 February 2020

9

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27 February 2020

author name string

Tatiana Goncharov

1

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27 February 2020

Kyle Niessen

2

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27 February 2020

Maria Cristina de Almagro

3

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27 February 2020

Anita Izrael-Tomasevic

4

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27 February 2020

Anna V Fedorova

5

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27 February 2020

Eugene Varfolomeev

6

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27 February 2020

David Arnott

7

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27 February 2020

Kurt Deshayes

8

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27 February 2020

Domagoj Vucic

10

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27 February 2020

language of work or name

English

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publication date

22 March 2013

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27 February 2020

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27 February 2020

volume

32

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27 February 2020

page(s)

1103-1114

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27 February 2020

issue

8

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Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

27 February 2020

cites work

1 reference

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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

19 March 2017

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Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

19 March 2017

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

19 March 2017

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19 March 2017

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Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

19 March 2017

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Structural basis and specificity of human otubain 1-mediated deubiquitination

19 March 2017

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

19 March 2017

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19 March 2017

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

19 March 2017

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

19 March 2017

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

19 March 2017

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The mechanism of OTUB1-mediated inhibition of ubiquitination

19 March 2017

1 reference

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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

19 March 2017

1 reference

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K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

19 March 2017

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Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

19 March 2017

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RING domain E3 ubiquitin ligases

19 March 2017

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19 March 2017

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

19 March 2017

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Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

19 March 2017

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

19 March 2017

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19 March 2017

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19 March 2017

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Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.

19 March 2017

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27 September 2017

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27 September 2017

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27 September 2017

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IAPs limit activation of RIP kinases by TNF receptor 1 during development

27 September 2017

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27 September 2017

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Endothelial development taking shape

27 September 2017

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27 September 2017

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

27 September 2017

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27 September 2017

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27 September 2017

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Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.

27 September 2017

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Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

27 September 2017

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Linear polyubiquitination: a new regulator of NF-kappaB activation.

27 September 2017

1 reference

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Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630360

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630360

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

27 September 2017

1 reference

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

27 September 2017

1 reference

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The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow.

27 September 2017

1 reference

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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3630360

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

29 November 2018

1 reference

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29 November 2018

Identifiers

DOI

10.1038/EMBOJ.2013.62

2 references

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27 February 2020

1 reference

2 references

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27 February 2020

2 references