Targeting IAP proteins for therapeutic intervention in cancer (Q37980321)

26 August 2017

Targeting IAP proteins for therapeutic intervention in cancer (English)

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26 August 2017

1

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26 August 2017

Domagoj Vucic

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26 August 2017

1 February 2012

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Nature Reviews Drug Discovery

26 August 2017

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26 August 2017

11

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26 August 2017

2

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26 August 2017

109-124

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https://scigraph.springernature.com/pub.10.1038/nrd3627

26 August 2017

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cites work

Hallmarks of Cancer: The Next Generation

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Tumor resistance to apoptosis

31 March 2020

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

31 March 2020

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IAP proteins: blocking the road to death's door

31 March 2020

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Targeting inhibitor of apoptosis proteins for therapeutic intervention.

31 March 2020

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IAPs, RINGs and ubiquitylation

31 March 2020

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(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways

31 March 2020

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Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

31 March 2020

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

31 March 2020

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A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors

31 March 2020

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A human IAP-family gene, apollon, expressed in human brain cancer cells

31 March 2020

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Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together

31 March 2020

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Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

31 March 2020

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NLR proteins: integral members of innate immunity and mediators of inflammatory diseases

31 March 2020

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Validating survivin as a cancer therapeutic target

31 March 2020

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The inhibitors of apoptosis (IAPs) as cancer targets

31 March 2020

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Unleashing the therapeutic potential of NOD-like receptors

31 March 2020

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

31 March 2020

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Targeting the extrinsic apoptosis pathway in cancer

31 March 2020

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Targeting mitochondria for cancer therapy

31 March 2020

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

31 March 2020

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

31 March 2020

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Structural basis of IAP recognition by Smac/DIABLO

31 March 2020

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The Bcl-2 apoptotic switch in cancer development and therapy

31 March 2020

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

31 March 2020

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

31 March 2020

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Mechanism of XIAP-mediated inhibition of caspase-9

31 March 2020

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Structural basis of caspase-7 inhibition by XIAP

31 March 2020

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Structural basis for the inhibition of caspase-3 by XIAP

31 March 2020

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Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

31 March 2020

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XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

31 March 2020

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Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

31 March 2020

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

31 March 2020

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

31 March 2020

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

31 March 2020

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

31 March 2020

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

31 March 2020

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Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

31 March 2020

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Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex

31 March 2020

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IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

31 March 2020

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

31 March 2020

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

31 March 2020

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

31 March 2020

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

31 March 2020

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

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Linear ubiquitination prevents inflammation and regulates immune signalling

31 March 2020

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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

31 March 2020

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

31 March 2020

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

31 March 2020

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

31 March 2020

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TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells

31 March 2020

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Rescue of TRAF3-null mice by p100 NF-kappa B deficiency

31 March 2020

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Classical and/or alternative NF-kappaB pathway activation in multiple myeloma

31 March 2020

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

31 March 2020

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

31 March 2020

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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

31 March 2020

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

31 March 2020

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

31 March 2020

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The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

31 March 2020

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

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A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

31 March 2020

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Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

31 March 2020

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MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression

31 March 2020

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A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

31 March 2020

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Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

31 March 2020

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The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

31 March 2020

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Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes

31 March 2020

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XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis

31 March 2020

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Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

31 March 2020

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Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia

31 March 2020

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High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

31 March 2020

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Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia

31 March 2020

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XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL.

31 March 2020

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Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia

31 March 2020

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The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays.

31 March 2020

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Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia.

31 March 2020

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Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

31 March 2020

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XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

31 March 2020

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Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas

31 March 2020

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Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients

31 March 2020

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Expression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosis

31 March 2020

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Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers

31 March 2020

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Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer

31 March 2020

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Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.

31 March 2020

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Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence

31 March 2020

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Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas

31 March 2020

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Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence

31 March 2020

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X-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinoma

31 March 2020

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Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma.

31 March 2020

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Assessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patients.

31 March 2020

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Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.

31 March 2020

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Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue.

31 March 2020

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Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas

31 March 2020

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ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

31 March 2020

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Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney.

31 March 2020

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Melanoma inhibitor of apoptosis protein is expressed differentially in melanoma and melanocytic naevus, but similarly in primary and metastatic melanomas

31 March 2020

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Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas

31 March 2020

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Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome

31 March 2020

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High nuclear Livin expression is a favourable prognostic indicator in renal cell carcinoma

31 March 2020

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Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer

31 March 2020

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Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors

31 March 2020

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Expression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNA-mediated silencing of livin gene

31 March 2020

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Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia.

31 March 2020

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Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome.

31 March 2020

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Livin and Bcl-2 expression in high-grade osteosarcoma

31 March 2020

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Expression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcome

31 March 2020

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Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance.

31 March 2020

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Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value

31 March 2020

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Prognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapy

31 March 2020

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Prognostic value of Smac expression in rectal cancer patients treated with neoadjuvant therapy

31 March 2020

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Correlation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patients

31 March 2020

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Prognostic significance of smac/DIABLO in endometrioid endometrial cancer

31 March 2020

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High Smac/DIABLO expression is associated with early local recurrence of cervical cancer

31 March 2020

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Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

31 March 2020

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The inhibitor of apoptosis proteins as therapeutic targets in cancer

31 March 2020

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Inhibition of reaper-induced apoptosis by interaction with inhibitor of apoptosis proteins (IAPs).

31 March 2020

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Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM.

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

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IAP-targeted therapies for cancer

31 March 2020

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Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)

31 March 2020

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The head involution defective gene of Drosophila melanogaster functions in programmed cell death

31 March 2020

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SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

31 March 2020

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Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

31 March 2020

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Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

31 March 2020

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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

31 March 2020

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Development of Peptidomimetics Targeting IAPs

31 March 2020

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Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners

31 March 2020

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Small-molecule pan-IAP antagonists: a patent review

31 March 2020

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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

31 March 2020

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A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

31 March 2020

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Design of small-molecule peptidic and nonpeptidic Smac mimetics

31 March 2020

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Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold

31 March 2020

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Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

31 March 2020

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Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

31 March 2020

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Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

31 March 2020

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A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo

31 March 2020

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X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists

31 March 2020

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XIAP discriminates between type I and type II FAS-induced apoptosis

31 March 2020

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Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

31 March 2020

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Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

31 March 2020

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Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

31 March 2020

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Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists

31 March 2020

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Targeting XIAP for the treatment of malignancy

31 March 2020

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Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

31 March 2020

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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

31 March 2020

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Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

31 March 2020

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Antisense therapy for cancer--the time of truth

31 March 2020

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Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

31 March 2020

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Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo.

31 March 2020

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XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer

31 March 2020

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Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

31 March 2020

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Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer

31 March 2020

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Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

31 March 2020

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XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML.

31 March 2020

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Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

31 March 2020

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XIAP-mediated protection of H460 lung cancer cells against cisplatin

31 March 2020

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Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

31 March 2020

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A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.

31 March 2020

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Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner

31 March 2020

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A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells

31 March 2020

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Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells

31 March 2020

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Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

31 March 2020

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Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

31 March 2020

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A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

31 March 2020

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Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

31 March 2020

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Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

31 March 2020

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Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells

31 March 2020

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A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells

31 March 2020

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Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene

31 March 2020

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Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib

31 March 2020

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A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.

31 March 2020

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Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound

31 March 2020

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Bypass NFkappaB-mediated survival pathways by TRAIL and Smac

31 March 2020

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A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.

31 March 2020

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Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis

31 March 2020

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TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors

31 March 2020

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The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.

31 March 2020

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Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

31 March 2020

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Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

31 March 2020

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Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment

31 March 2020

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Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.

31 March 2020

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A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

31 March 2020

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Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.

31 March 2020

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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

31 March 2020

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TNF-alpha induces two distinct caspase-8 activation pathways

31 March 2020

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Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

31 March 2020

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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

31 March 2020

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Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma

31 March 2020

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Sensitization of pancreatic carcinoma cells for γ-irradiation-induced apoptosis by XIAP inhibition

31 March 2020

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Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis.

31 March 2020

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NF-κB is required for Smac mimetic-mediated sensitization of glioblastoma cells for γ-irradiation-induced apoptosis

31 March 2020

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Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

31 March 2020

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Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins

31 March 2020

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Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer

31 March 2020

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Smac mimetics: implications for enhancement of targeted therapies in leukemia

31 March 2020

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X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor

31 March 2020

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Beneficial effects of combining a type II ATP competitive inhibitor with an allosteric competitive inhibitor of BCR-ABL for the treatment of imatinib-sensitive and imatinib-resistant CML.

31 March 2020

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IAP inhibitors enhance co-stimulation to promote tumor immunity

31 March 2020

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Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

31 March 2020

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

31 March 2020

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A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment

31 March 2020

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A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

31 March 2020

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Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias

31 March 2020

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12 December 2020

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors

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12 December 2020

Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.

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12 December 2020

Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma

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12 December 2020

Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis

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12 December 2020

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

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12 December 2020

Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization.

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12 December 2020

An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs

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12 December 2020

The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas

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12 December 2020

Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients

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12 December 2020

Clinical significance of Smac/DIABLO expression in colorectal cancer

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12 December 2020

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

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12 December 2020

XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer.

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12 December 2020

Expression of Smac/DIABLO is a novel prognostic marker in lung cancer.

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12 December 2020

Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide

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12 December 2020

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

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12 December 2020

Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.

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12 December 2020

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

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12 December 2020

Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents

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12 December 2020

Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer

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12 December 2020

Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis

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12 December 2020

Elevated expression of inhibitor of apoptosis proteins in prostate cancer

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12 December 2020

X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells

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12 December 2020

Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy

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12 December 2020

Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18

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12 December 2020

Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.

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12 December 2020

Structural Basis of Caspase Inhibition by XIAP

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12 December 2020

Identifiers

DOI

10.1038/NRD3627

1 reference

26 August 2017

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PubMed ID

22293567