Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1 (Q24337301)

positive regulation of insulin receptor signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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9

Hubert Vidal

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Florence Solari

Florence Solari

8

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Luciano Pirola

Luciano Pirola

10

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Assam El-osta

Assam El-Osta

5

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Andrew L Carey

Andrew L Carey

4

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author name string

Sara Fröjdö

1

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Christine Durand

2

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Laurent Molin

3

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Bronwyn A Kingwell

6

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Mark A Febbraio

Molecular and Cellular Endocrinology

7

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language of work or name

English

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publication date

30 March 2011

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published in

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volume

335

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page(s)

166-76

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issue

2

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cites work

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

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SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

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IGF-1 signaling and aging.

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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

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Resveratrol improves health and survival of mice on a high-calorie diet

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha

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The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans

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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

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Resveratrol inhibits insulin responses in a SirT1-independent pathway

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Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

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Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

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The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

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Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

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Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

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Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner

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FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

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Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

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Substrate-specific activation of sirtuins by resveratrol

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Mechanism of human SIRT1 activation by resveratrol

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

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7 January 2021

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

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Metabolic benefits from Sirt1 and Sirt1 activators

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Remarkable longevity and stress resistance of nematode PI3K-null mutants

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The endocrine regulation of aging by insulin-like signals

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SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

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Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

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Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

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Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway

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Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms

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JNK2-dependent regulation of SIRT1 protein stability

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Resveratrol: a multitargeted agent for age-associated chronic diseases.

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