Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases (Q24337797)

Ral GTPase activating protein catalytic subunit alpha 1

GOA release 2020-03-11

1 reference

protein heterodimerization activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

9

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author name string

Ryutaro Shirakawa

1

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Shuya Fukai

2

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Mitsunori Kawato

3

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Tomohito Higashi

4

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Hirokazu Kondo

5

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Tomoyuki Ikeda

6

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Ei Nakayama

7

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Katsuya Okawa

8

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Takeshi Kimura

10

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Toru Kita

11

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Hisanori Horiuchi

Journal of Biological Chemistry

12

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language of work or name

English

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publication date

7 August 2009

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published in

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volume

284

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issue

32

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page(s)

21580-8

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cites work

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

19 March 2017

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

19 March 2017

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Adipocytes contain a novel complex similar to the tuberous sclerosis complex

19 March 2017

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

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The GTPase-activating protein Rap1GAP uses a catalytic asparagine

19 March 2017

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

19 March 2017

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RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

19 March 2017

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Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex

19 March 2017

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The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene

19 March 2017

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Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral

19 March 2017

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Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation

19 March 2017

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Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase

19 March 2017

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Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

19 March 2017

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Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

19 March 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

19 March 2017

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GEFs and GAPs: critical elements in the control of small G proteins

19 March 2017

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Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue

19 March 2017

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

19 March 2017

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

19 March 2017

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

19 March 2017

1 reference

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The exocyst complex binds the small GTPase RalA to mediate filopodia formation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral

19 March 2017

1 reference

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A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras

19 March 2017

1 reference

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Stimulation of gene induction and cell growth by the Ras effector Rlf

19 March 2017

1 reference

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The tuberous sclerosis complex

19 March 2017

1 reference

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Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

1 reference

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Ral GTPases and cancer: linchpin support of the tumorigenic platform

7 April 2017

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Expression of ral GTPases, their effectors, and activators in human bladder cancer

27 September 2017

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Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase

27 September 2017

1 reference

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Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Ral GTPases: corrupting the exocyst in cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

RalGDS is required for tumor formation in a model of skin carcinogenesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Ral-GTPases: approaching their 15 minutes of fame

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Distinct requirements for Ras oncogenesis in human versus mouse cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Ras-dependent activation of the small GTPase Ral.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

ralGDS family members interact with the effector loop of ras p21.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Characterization of a GTPase-activating protein for the Ras-related Ral protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.012112

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755882

Species- and cell type-specific requirements for cellular transformation

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19520869

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The exocyst is a Ral effector complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19520869