epidermal growth factor receptor (Q424401)

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mammalian protein found in Homo sapiens
  • erb-b2 receptor tyrosine kinase 1
  • cell proliferation-inducing protein 61
  • receptor tyrosine-protein kinase erbB-1
  • epidermal growth factor receptor tyrosine kinase domain
  • EGFR
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
  • proto-oncogene c-ErbB-1
  • cell growth inhibiting protein 40
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Language Label Description Also known as
English
epidermal growth factor receptor
mammalian protein found in Homo sapiens
  • erb-b2 receptor tyrosine kinase 1
  • cell proliferation-inducing protein 61
  • receptor tyrosine-protein kinase erbB-1
  • epidermal growth factor receptor tyrosine kinase domain
  • EGFR
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
  • proto-oncogene c-ErbB-1
  • cell growth inhibiting protein 40

Statements

part of
molecular function
identical protein binding
determination method
IPI
18 references
retrieved
1 January 2018
stated in
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
In situ analysis of mutant EGFRs prevalent in glioblastoma multiforme reveals aberrant dimerization, activation, and differential response to anti-EGFR targeted therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Parallel visualization of multiple protein complexes in individual cells in tumor tissue
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A proximity ligation assay using transiently transfected, epitope-tagged proteins: application for in situ detection of dimerized receptor tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Insights into the aberrant activity of mutant EGFR kinase domain and drug recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Conformational coupling across the plasma membrane in activation of the EGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Comparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
protein tyrosine kinase activity
determination method
IEA
IMP
TAS
IDA
EXP
10 references
retrieved
1 January 2018
stated in
The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
TAS
retrieved
1 January 2018
stated in
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IMP
retrieved
1 January 2018
stated in
Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
Tyrosine phosphorylation controls PCNA function through protein stability
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
EXP
epidermal growth factor-activated receptor activity
determination method
IDA
IEA
IMP
NAS
6 references
retrieved
31 October 2017
stated in
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
NAS
retrieved
31 October 2017
stated in
ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
NAS
retrieved
31 October 2017
stated in
Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IMP
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
31 October 2017
stated in
Tyrosine phosphorylation controls PCNA function through protein stability
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
31 October 2017
stated in
Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P00533&geneProductId=UniProtKB:P00533
determination method
IDA
protein binding
determination method
IPI
131 references
retrieved
1 January 2018
stated in
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Tyrosine phosphorylation controls PCNA function through protein stability
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Substrate specificity of the protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Parallel visualization of multiple protein complexes in individual cells in tumor tissue
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR/Met association regulates EGFR TKI resistance in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Survival of cancer cells is maintained by EGFR independent of its kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Epidermal growth factor directs sex-specific steroid signaling through Src activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Subsets of epidermal growth factor receptors during activation and endocytosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by pulmonary epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A novel proteomic screen for peptide-protein interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Threshold-controlled ubiquitination of the EGFR directs receptor fate
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Identification of 14-3-3zeta as an EGF receptor interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A kinase-independent role for EGF receptor in autophagy initiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
GOLM1 Modulates EGFR/RTK Cell-Surface Recycling to Drive Hepatocellular Carcinoma Metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Insights into the aberrant activity of mutant EGFR kinase domain and drug recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Determinants of substrate recognition in the protein-tyrosine phosphatase, PTP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Flow cytometric in situ proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Ligand-induced structural transitions in ErbB receptor extracellular domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
retrieved
1 January 2018
stated in
Mycoplasma hyorhinis infection promotes NF-κB-dependent migration of gastric cancer cells
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IPI
epidermal growth factor-activated receptor activity
determination method
IBA
IDA
IEA
IMP
NAS
7 references
retrieved
1 January 2018
stated in
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
NAS
retrieved
1 January 2018
stated in
ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
NAS
retrieved
1 January 2018
stated in
Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
Tyrosine phosphorylation controls PCNA function through protein stability
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IBA
protein tyrosine kinase activity
determination method
IDA
IEA
IMP
TAS
9 references
retrieved
1 January 2018
stated in
The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
TAS
retrieved
1 January 2018
stated in
Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IMP
retrieved
1 January 2018
stated in
Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IMP
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
Tyrosine phosphorylation controls PCNA function through protein stability
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
cell component
endosome
determination method
IDA
IEA
6 references
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
plasma membrane
determination method
IDA
TAS
IEA
7 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IEA
retrieved
1 January 2018
stated in
The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P00533
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
retrieved
1 January 2018
stated in
Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00533
determination method
IDA
biological process
physically interacts with

Identifiers

MeSH descriptor ID
C512478
subject named as
EGFR protein, human
0 references
UniProt protein ID
P00533
0 references
Ensembl protein ID
ENSP00000275493
0 references
ENSP00000342376
0 references
ENSP00000345973
0 references
ENSP00000413843
0 references
ENSP00000395243
0 references
ENSP00000413354
0 references
ENSP00000415559
0 references
ENSP00000492462
0 references
Microsoft Academic ID
2777506169
0 references
2779438470
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q424401&oldid=2139458088"