Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway (Q24339384)

GOA release 2020-03-11

Unc-51 like kinase 3

1 reference

GOA release 2020-03-11

protein kinase binding

1 reference

GOA release 2020-03-11

4

Lauri Peil

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author name string

Alla Maloverjan

1

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Marko Piirsoo

2

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Lagle Kasak

3

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Torben Østerlund

5

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Priit Kogerman

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

24 September 2010

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published in

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volume

285

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issue

39

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page(s)

30079-90

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cites work

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Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

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Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

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Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

19 March 2017

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Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

19 March 2017

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Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

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19 March 2017

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

19 March 2017

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

19 March 2017

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Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

19 March 2017

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Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

19 March 2017

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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

19 March 2017

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19 March 2017

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19 March 2017

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19 March 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling

27 September 2017

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Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site

27 September 2017

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Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused

27 September 2017

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The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling

27 September 2017

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Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943318

Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila

27 September 2017

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Phosphorylation of the fused protein kinase in response to signaling from hedgehog

27 September 2017

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Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.

27 September 2017

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The Suppressor of fused gene encodes a novel PEST protein involved in Drosophila segment polarity establishment

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943318

Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster

27 September 2017

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Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators

27 September 2017

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Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

30 May 2018

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

30 May 2018

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A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

30 May 2018

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Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis

30 May 2018

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Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

21 January 2018

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Genetic dissection of the Drosophila Cubitus interruptus signaling complex

21 January 2018

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Identification of a tetrameric hedgehog signaling complex

21 January 2018

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Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

21 January 2018

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Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.

21 January 2018

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Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.

21 January 2018

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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

21 January 2018

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Sample preparation by SDS/PAGE and in-gel digestion

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20643644

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20643644