Structure and function of the platelet integrin alphaIIbbeta3 (Q24536159)

Journal of Clinical Investigation

Europe PubMed Central

title

Structure and function of the platelet integrin alphaIIbbeta3 (English)

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author name string

Joel S Bennett

series ordinal

1

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language of work or name

English

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publication date

December 2005

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published in

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volume

115

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issue

12

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page(s)

3363-9

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cites work

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Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain

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Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia

24 March 2017

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ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation

24 March 2017

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Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3

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Integrin structure, allostery, and bidirectional signaling

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Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.

27 September 2017

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A push-pull mechanism for regulating integrin function

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CD98hc (SLC3A2) mediates integrin signaling.

27 September 2017

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27 September 2017

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

27 September 2017

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Protein-protein interactions in platelet alphaIIbbeta3 signaling

27 September 2017

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Functional and structural correlations of individual alphaIIbbeta3 molecules

27 September 2017

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Talin controls integrin activation

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Structural basis for integrin alphaIIbbeta3 clustering.

27 September 2017

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Membrane-mediated structural transitions at the cytoplasmic face during integrin activation

27 September 2017

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Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits

27 September 2017

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Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling

27 September 2017

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New insights into the structural basis of integrin activation.

27 September 2017

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Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography

27 September 2017

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Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa.

27 September 2017

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Transmembrane signal transduction of the alpha(IIb)beta(3) integrin

27 September 2017

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Integrin tyrosine phosphorylation in platelet signaling

27 September 2017

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NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution

27 September 2017

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Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain

27 September 2017

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Helical membrane protein folding, stability, and evolution

27 September 2017

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The GxxxG motif: a framework for transmembrane helix-helix association

27 September 2017

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The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

27 September 2017

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Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformations

27 September 2017

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A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding

27 September 2017

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Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex

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27 September 2017

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Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine

27 September 2017

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Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.

27 September 2017

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Integrin cytoplasmic domains mediate inside-out signal transduction

27 September 2017

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Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human platelets

27 September 2017

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The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen

27 September 2017

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Glanzmann's thrombasthenia: the spectrum of clinical disease

27 September 2017

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Role of fibrinogen alpha and gamma chain sites in platelet aggregation

27 September 2017

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Exposure of platelet fibrinogen receptors by ADP and epinephrine

27 September 2017

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Adhesion of platelets to laminin in the absence of activation

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Sequence context strongly modulates association of polar residues in transmembrane helices

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

30 May 2018

1 reference

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Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis

30 May 2018

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Structural biology of glycoprotein IIb-IIIa

30 May 2018

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A coiled-coil structure of the alphaIIbbeta3 integrin transmembrane and cytoplasmic domains in its resting state

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Evidence for hetero-association of transmembrane helices of integrins

29 November 2018

1 reference

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

29 November 2018

1 reference

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Concurrent signaling from Galphaq- and Galphai-coupled pathways is essential for agonist-induced alphavbeta3 activation on human platelets

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

29 November 2018

1 reference

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

29 November 2018

1 reference

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Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297263

Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets.

29 November 2018

1 reference

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A mechanism for divalent cation regulation of beta 3-integrins.

29 November 2018

1 reference

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Laminin receptor on platelets is the integrin VLA-6.

29 November 2018

1 reference

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The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets

29 November 2018

1 reference

12 December 2020

Determination of the Border between the Transmembrane and Cytoplasmic Domains of Human Integrin Subunits

1 reference

12 December 2020

Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein

1 reference

12 December 2020

Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chain

1 reference

12 December 2020

Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis

1 reference

12 December 2020

The cytoplasmic domain of alphaIIb beta3. A ternary complex of the integrin alpha and beta subunits and a divalent cation

1 reference

12 December 2020

Increased surface expression of the membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship to the binding of fibrinogen and platelet aggregation

1 reference

12 December 2020

Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy

1 reference

12 December 2020

Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex

1 reference

12 December 2020

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI26989

1 reference

1 reference

1 reference

PubMed publication ID

16322781

1 reference