Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function (Q24608468)

The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP

Europe PubMed Central

title

Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function (English)

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1 reference

Gary J Bassell

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Stephen T Warren

series ordinal

2

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language of work or name

English

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publication date

23 October 2008

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published in

Neuron

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volume

60

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issue

2

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page(s)

201-14

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cites work

1 reference

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Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

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Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome

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Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes

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FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

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A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability

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Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses

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Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons

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Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome

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Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression

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Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons

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The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses

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The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif

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Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes

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Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

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Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

7 April 2017

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Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD

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Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus

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The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules

7 April 2017

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Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors

7 April 2017

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The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons

7 April 2017

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Functional and selective RNA interference in developing axons and growth cones

7 April 2017

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Visual experience regulates transient expression and dendritic localization of fragile X mental retardation protein

7 April 2017

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Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA

7 April 2017

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Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses

7 April 2017

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Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses

7 April 2017

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Transport of fragile X mental retardation protein via granules in neurites of PC12 cells

7 April 2017

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The fragile X mental retardation protein inhibits translation via interacting with mRNA

7 April 2017

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

7 April 2017

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A brain-specific microRNA regulates dendritic spine development

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7 April 2017

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Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

7 April 2017

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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

7 April 2017

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Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome

7 April 2017

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Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate

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Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA

27 September 2017

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Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

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Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice.

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S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade

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Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning

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Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR

27 September 2017

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Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes

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Dendritic mRNA: transport, translation and function

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RNA transport and localized protein synthesis in neurological disorders and neural repair

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The pathophysiology of fragile x syndrome.

27 September 2017

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FMRP mediates mGluR5-dependent translation of amyloid precursor protein

27 September 2017

1 reference

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Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies

27 September 2017

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Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome.

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Neuronal RNA granules: movers and makers

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Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond.

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Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

27 September 2017

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The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain

27 September 2017

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Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.

27 September 2017

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Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

27 September 2017

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The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.

27 September 2017

1 reference

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Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles

27 September 2017

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Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.

27 September 2017

1 reference

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The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

27 September 2017

1 reference

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Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and β-Actin mRNA in Dendrites and Spines of Hippocampal Neurons

27 September 2017

1 reference

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Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface

27 September 2017

1 reference

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Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression

27 September 2017

1 reference

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N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses

27 September 2017

1 reference

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Dendritic spine structural anomalies in fragile-X mental retardation syndrome

27 September 2017

1 reference

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No evidence for disruption of normal patterns of mRNA localization in dendrites or dendritic transport of recently synthesized mRNA in FMR1 knockout mice, a model for human fragile-X mental retardation syndrome

27 September 2017

1 reference

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A nuclear role for the Fragile X mental retardation protein

27 September 2017

1 reference

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Further segregation analysis of the fragile X syndrome with special reference to transmitting males

27 September 2017

1 reference

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Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms

27 September 2017

1 reference

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DNA methylation represses FMR-1 transcription in fragile X syndrome

27 September 2017

1 reference

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Neuroscience: fragile dopamine

30 May 2018

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FMRP acts as a key messenger for dopamine modulation in the forebrain

28 November 2018

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The ups and downs of translation-dependent plasticity.

28 November 2018

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Heterogeneous dysregulation of microRNAs across the autism spectrum.

28 November 2018

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Reply to Bagni: On BC1 RNA and the fragile X mental retardation protein

28 November 2018

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28 November 2018

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Reducing glutamate signaling pays off in fragile X.

28 November 2018

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FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Fragile X tremor/ataxia syndrome: blame the messenger!

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Fragile X-associated tremor/ataxia syndrome--an older face of the fragile X gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

RNAi pathway is functional in peripheral nerve axons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Decreased expression of the GABAA receptor in fragile X syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

The mRNA for elongation factor 1alpha is localized in dendrites and translated in response to treatments that induce long-term depression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Phosphorylation influences the translation state of FMRP-associated polyribosomes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

The fragile X mental retardation protein interacts with U-rich RNAs in a yeast three-hybrid system

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3691995

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18957214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

On BC1 RNA and the fragile X mental retardation protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18957214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18957214

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEURON.2008.10.004

1 reference

559073

559073

1 reference

1 reference

1 reference