Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice (Q24628256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962218%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962218%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Alejandro López Tobón

3

1 reference

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15 February 2020

Ryan L. Boudreau

7

1 reference

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Gloria Patricia Cardona-Gomez

15 February 2020

12

1 reference

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15 February 2020

11

Kenneth S Kosik

1 reference

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15 February 2020

author name string

Diego Piedrahita

1

1 reference

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15 February 2020

Israel Hernández

2

1 reference

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15 February 2020

Dmitry Fedorov

4

1 reference

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15 February 2020

Boguslaw Obara

5

1 reference

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15 February 2020

B S Manjunath

6

1 reference

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15 February 2020

Beverly Davidson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962218%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Frank Laferla

9

1 reference

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15 February 2020

Juan Carlos Gallego-Gómez

10

1 reference

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15 February 2020

language of work or name

English

0 references

publication date

1 October 2010

1 reference

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15 February 2020

published in

Journal of Neuroscience

1 reference

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15 February 2020

volume

30

1 reference

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15 February 2020

issue

42

1 reference

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15 February 2020

page(s)

13966-13976

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962218%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

15 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3003593/fullTextXML

inferred from PubMed Central ID database lookup

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

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Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

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Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

27 September 2017

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Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

27 September 2017

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Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications

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A novel approach to cyclin-dependent kinase 5/p25 inhibitors: A potential treatment for Alzheimer's disease

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

30 May 2018

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Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors

30 May 2018

1 reference

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28 November 2018

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Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus

28 November 2018

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Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.

28 November 2018

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Molecular neuroadaptations in the accumbens and ventral tegmental area during the first 90 days of forced abstinence from cocaine self-administration in rats

28 November 2018

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Cdk5 is a key factor in tau aggregation and tangle formation in vivo

28 November 2018

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28 November 2018

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

28 November 2018

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Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice

28 November 2018

1 reference

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Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

28 November 2018

1 reference

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Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

28 November 2018

1 reference

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A brain-specific activator of cyclin-dependent kinase 5.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003593

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20962218

12 December 2020

inferred from PubMed ID database lookup

An experimental comparison of min-cut/max-flow algorithms for energy minimization in vision.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20962218

12 December 2020

inferred from PubMed ID database lookup

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20962218

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.3637-10.2010

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962218%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20962218%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

20962218

2 references