Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector (Q24631549)

19 October 2023

John J Lee

2

John J

Lee

1 reference

19 October 2023

James Kim

3

James

Kim

1 reference

19 October 2023

Dale Gardner

4

Dale

Gardner

1 reference

19 October 2023

Philip A Beachy

5

Philip A

Beachy

1 reference

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

language of work or name

English

0 references

publication date

27 July 2010

0 references

published in

0 references

volume

107

0 references

issue

30

0 references

page(s)

13432-7

0 references

cites work

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

7 April 2017

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Small molecule modulation of Smoothened activity

7 April 2017

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Activating Smoothened mutations in sporadic basal-cell carcinoma

7 April 2017

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

7 April 2017

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

7 April 2017

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Vertebrate Smoothened functions at the primary cilium

7 April 2017

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Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

7 April 2017

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Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

7 April 2017

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Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide

7 April 2017

1 reference

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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

7 April 2017

1 reference

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Hedgehog signaling in animal development: paradigms and principles

7 April 2017

1 reference

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

7 April 2017

1 reference

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

7 April 2017

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Human homolog of patched, a candidate gene for the basal cell nevus syndrome

7 April 2017

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Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas

7 April 2017

1 reference

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

7 April 2017

1 reference

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Patched1 regulates hedgehog signaling at the primary cilium

7 April 2017

1 reference

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Hedgehog: functions and mechanisms

7 April 2017

1 reference

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Neuronal specification in the spinal cord: inductive signals and transcriptional codes

7 April 2017

1 reference

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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Hedgehog beyond medulloblastoma and basal cell carcinoma

27 September 2017

1 reference

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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

GDC-0449-a potent inhibitor of the hedgehog pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

A paracrine requirement for hedgehog signalling in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Arsenic trioxide decreases AKT protein in a caspase-dependent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Essential role of stromally induced hedgehog signaling in B-cell malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor-alpha.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Invited Reviews: Carcinogenic and Systemic Health Effects Associated with Arsenic Exposure—A Critical Review

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Mutations in SUFU predispose to medulloblastoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Signal transduction pathways regulated by arsenate and arsenite

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Teratogenic response to arsenite during neurulation: relative sensitivities of C57BL/6J and SWV/Fnn mice and impact of the splotch allele

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

A frequent activated smoothened mutation in sporadic basal cell carcinomas

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Amplification of the gli gene in childhood sarcomas.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922148

Loss of suppressor-of-fused function promotes tumorigenesis.

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

An assessment of the developmental toxicity of inorganic arsenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

Embryotoxic effects of sodium arsenite and sodium arsenate on mouse embryos in culture

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20624968

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1006822107

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1073/PNAS.1006822107

1 reference

ADS bibcode

2010PNAS..10713432K

0 references

1 reference

1 reference

1 reference