Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding (Q24632948)

1

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Divya S Vinjamur

2

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Mohua Basu

3

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Karin M L Gaensler

5

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Joyce A Lloyd

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

15 July 2011

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published in

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volume

286

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issue

28

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page(s)

24819-27

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cites work

A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia

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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

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A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo

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EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis

7 April 2017

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A global role for EKLF in definitive and primitive erythropoiesis

7 April 2017

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KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo

7 April 2017

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The active spatial organization of the beta-globin locus requires the transcription factor EKLF

7 April 2017

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Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development

7 April 2017

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Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

7 April 2017

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Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

7 April 2017

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Loss of LKLF function results in embryonic lethality in mice

7 April 2017

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Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells

7 April 2017

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Position-independent, high-level expression of the human beta-globin gene in transgenic mice

7 April 2017

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Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

7 April 2017

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Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf

27 September 2017

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Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor

27 September 2017

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A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci

27 September 2017

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The higher structure of chromatin in the LCR of the beta-globin locus changes during development

27 September 2017

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BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription

27 September 2017

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Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression

27 September 2017

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KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors

27 September 2017

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Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.

27 September 2017

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Joining the loops: beta-globin gene regulation

27 September 2017

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Epigenetics of beta-globin gene regulation

27 September 2017

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Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus

27 September 2017

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Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells.

27 September 2017

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Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites

27 September 2017

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Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

27 September 2017

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Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.

27 September 2017

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Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences

27 September 2017

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Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

27 September 2017

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Lineage-specific activators affect beta-globin locus chromatin in multipotent hematopoietic progenitors

27 September 2017

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Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region

27 September 2017

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Hematopoiesis in the yolk sac: more than meets the eye.

27 September 2017

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The specification of early hematopoiesis in the mammal.

27 September 2017

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Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development

27 September 2017

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KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation

27 September 2017

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GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling

27 September 2017

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Krüppel-like factors: three fingers in many pies

27 September 2017

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Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

27 September 2017

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Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice

27 September 2017

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Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression

27 September 2017

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DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression

27 September 2017

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27 September 2017

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A core Klf circuitry regulates self-renewal of embryonic stem cells.

21 January 2018

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Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system

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Crosstalk between histone modifications maintains the developmental pattern of gene expression on a tissue-specific locus.

21 January 2018

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KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching

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21 January 2018

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