Control of cell growth by the SCF and APC/C ubiquitin ligases (Q24647543)

Current Opinion in Cell Biology

Europe PubMed Central

title

Control of cell growth by the SCF and APC/C ubiquitin ligases (English)

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author name string

Jeffrey R Skaar

series ordinal

1

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language of work or name

English

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publication date

December 2009

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published in

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volume

21

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issue

6

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page(s)

816-24

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cites work

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The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

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The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

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Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

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Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex

7 April 2017

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7 April 2017

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VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

7 April 2017

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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

7 April 2017

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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

7 April 2017

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CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

7 April 2017

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NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

7 April 2017

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

7 April 2017

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The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1

7 April 2017

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

7 April 2017

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The spindle-assembly checkpoint in space and time

7 April 2017

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7 April 2017

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Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

7 April 2017

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Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

7 April 2017

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Function and regulation of cullin-RING ubiquitin ligases

7 April 2017

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betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

7 April 2017

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Control of chromosome stability by the beta-TrCP-REST-Mad2 axis

7 April 2017

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

7 April 2017

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Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

7 April 2017

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Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

7 April 2017

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7 April 2017

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The SCF ubiquitin ligase: insights into a molecular machine

7 April 2017

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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

7 April 2017

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Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

7 April 2017

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Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

7 April 2017

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Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

7 April 2017

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Themes and variations on ubiquitylation

7 April 2017

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

7 April 2017

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

7 April 2017

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The anaphase promoting complex/cyclosome: a machine designed to destroy

7 April 2017

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Ubiquitin ligases: cell-cycle control and cancer

7 April 2017

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APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

7 April 2017

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Identification of SCF ubiquitin ligase substrates by global protein stability profiling

27 September 2017

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Global protein stability profiling in mammalian cells

27 September 2017

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The COP9 signalosome: more than a protease

27 September 2017

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Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

27 September 2017

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A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells

27 September 2017

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Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

27 September 2017

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Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

27 September 2017

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27 September 2017

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A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation

27 September 2017

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The anaphase-promoting complex/cyclosome: APC/C.

27 September 2017

1 reference

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Interwoven ubiquitination oscillators and control of cell cycle transitions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Nedd8 on cullin: building an expressway to protein destruction.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

The ubiquitin-proteasome pathway and pathogenesis of human diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

PARC and CUL7 form atypical cullin RING ligase complexes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2805079