MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. (Q34489720)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013216%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

title

MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis (English)

1 reference

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31 October 2019

3

1 reference

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31 October 2019

author name string

G Ganguli

series ordinal

1

1 reference

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31 October 2019

J Abecassis

series ordinal

2

1 reference

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31 October 2019

language of work or name

English

0 references

publication date

1 October 2000

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31 October 2019

1 reference

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31 October 2019

volume

19

1 reference

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31 October 2019

issue

19

1 reference

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31 October 2019

page(s)

5135-5147

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The INK4a/ARF locus in murine tumorigenesis

31 October 2019

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E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction

6 July 2018

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Ultraviolet radiation-induced p53 responses in the epidermis are differentiation-dependent

6 July 2018

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

6 July 2018

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p63 is a p53 homologue required for limb and epidermal morphogenesis

6 July 2018

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

6 July 2018

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6 July 2018

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A common human skin tumour is caused by activating mutations in beta-catenin

6 July 2018

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Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

6 July 2018

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6 July 2018

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MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.

6 July 2018

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Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

6 July 2018

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p53-independent role of MDM2 in TGF-beta1 resistance

6 July 2018

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

6 July 2018

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Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation

6 July 2018

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Inhibition of UV-induced p53 mutations by sunscreens: implications for skin cancer prevention.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Mdm2: keeping p53 under control

6 July 2018

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Regulation of p53 stability by Mdm2

6 July 2018

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Mdm2 promotes the rapid degradation of p53

6 July 2018

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6 July 2018

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The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation

6 July 2018

1 reference

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MDM-2 protein is expressed in different layers of normal human skin

6 July 2018

1 reference

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Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy

6 July 2018

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6 July 2018

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Frequent clones of p53-mutated keratinocytes in normal human skin

6 July 2018

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Amplification of MDM2 inhibits MyoD-mediated myogenesis

6 July 2018

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The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target

6 July 2018

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6 July 2018

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Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells

6 July 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

6 July 2018

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

6 July 2018

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6 July 2018

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6 July 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

6 July 2018

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p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein

6 July 2018

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6 July 2018

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6 July 2018

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Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes

6 July 2018

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The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies.

6 July 2018

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Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

6 July 2018

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Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation

6 July 2018

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6 July 2018

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Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation

6 July 2018

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Sequence and expression of a type II keratin, K5, in human epidermal cells

6 July 2018

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Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

6 July 2018

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Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation

6 July 2018

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Amplification of a gene encoding a p53-associated protein in human sarcomas

6 July 2018

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Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis

6 July 2018

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Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene

6 July 2018

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p53 protects against skin cancer induction by UV-B radiation.

21 January 2018

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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p53-dependent regulation of nucleotide excision repair in murine epidermis in vivo.

21 January 2018

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p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes

21 January 2018

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Sunburn and p53 in the onset of skin cancer

21 January 2018

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21 January 2018

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12 December 2020

MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins

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12 December 2020

Overproduction of MDM2 in vivo disrupts S phase independent of E2F1

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12 December 2020

High levels of p53 protein in UV-irradiated normal human skin

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Identifiers

DOI

10.1093/EMBOJ/19.19.5135

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013216%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11013216%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1 reference