Selectivity and therapeutic inhibition of kinases: to be or not to be? (Q24656006)

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Europe PubMed Central

title

Selectivity and therapeutic inhibition of kinases: to be or not to be? (English)

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author name string

Kamran Ghoreschi

series ordinal

1

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Arian Laurence

series ordinal

2

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John J O'Shea

series ordinal

3

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language of work or name

English

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publication date

April 2009

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published in

Nature Immunology

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volume

10

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page(s)

356-60

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issue

4

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cites work

1 reference

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7 April 2017

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7 April 2017

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

7 April 2017

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Activation of tyrosine kinases by mutation of the gatekeeper threonine

7 April 2017

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

7 April 2017

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

7 April 2017

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

7 April 2017

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Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

7 April 2017

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

7 April 2017

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Protein modules and signalling networks

7 April 2017

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

7 April 2017

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A quantitative analysis of kinase inhibitor selectivity

7 April 2017

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Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity

7 April 2017

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

7 April 2017

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

7 April 2017

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Jak2 is essential for signaling through a variety of cytokine receptors

7 April 2017

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

7 April 2017

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Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

7 April 2017

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

7 April 2017

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

7 April 2017

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

7 April 2017

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

7 April 2017

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

7 April 2017

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Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

7 April 2017

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The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Partial impairment of cytokine responses in Tyk2-deficient mice

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

28 September 2017

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Relationship of structure to function of muscle phosphorylase

28 September 2017

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A thousand and one protein kinases

28 September 2017

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

28 September 2017

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Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Phase 1 dose-escalation study of CP-690 550 in stable renal allograft recipients: preliminary findings of safety, tolerability, effects on lymphocyte subsets and pharmacokinetics

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758543

Getting down to specifics

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19295632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19295632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.1701

1 reference

2010432

2010432

1 reference

1 reference

1 reference