A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines (Q24792846)

8

object named as

Ragnhild A Lothe

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author name string

Guro E Lind

1

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Lin Thorstensen

2

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Tone Løvig

3

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Gunn I Meling

4

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Richard Hamelin

5

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Torleiv O Rognum

CpG island methylator phenotype in colorectal cancer

6

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language of work or name

English

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publication date

11 October 2004

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published in

Molecular Cancer

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volume

3

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issue

1

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page(s)

28

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cites work

1 reference

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Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer

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Methylation of selected CpGs in the human O6-methylguanine-DNA methyltransferase promoter region as a marker of gene silencing

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

28 September 2017

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28 September 2017

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X chromosome imprinting and inactivation in the early mammalian embryo

28 September 2017

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28 September 2017

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A systematic profile of DNA methylation in human cancer cell lines

28 September 2017

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Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer

30 May 2018

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CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

30 May 2018

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Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.

30 May 2018

1 reference

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Alterations in DNA methylation: a fundamental aspect of neoplasia

30 May 2018

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

30 May 2018

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30 May 2018

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Colorectal cancers with both p16 and p14 methylation show invasive characteristics.

28 November 2018

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28 November 2018

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APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status.

28 November 2018

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28 November 2018

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28 November 2018

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Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.

28 November 2018

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DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

28 November 2018

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Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability.

28 November 2018

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Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.

28 November 2018

1 reference

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Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

28 November 2018

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Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer

28 November 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=526388

Gender difference for mismatch repair deficiency in human colorectal cancer

28 November 2018

1 reference

12 December 2020

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history

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12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

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12 December 2020

Association between CpG island methylation and microsatellite instability in colorectal cancer

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12 December 2020

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

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12 December 2020

TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival

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12 December 2020

Reduced genomic 5-methylcytosine content in human colonic neoplasia

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12 December 2020

E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas

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12 December 2020

Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women

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12 December 2020

Methylation of CpG loci in 5'-flanking region alters steady-state expression of adenomatous polyposis coli gene in colon cancer cell lines

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12 December 2020

Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability

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12 December 2020

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

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12 December 2020

Densely methylated MLH1 promoter correlates with decreased mRNA expression in sporadic colorectal cancers

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12 December 2020

Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer

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12 December 2020

The fundamental role of epigenetic events in cancer

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12 December 2020

Identifiers

DOI

10.1186/1476-4598-3-28

1 reference

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-3-28

1 reference

1 reference

PubMed publication ID

15476557

1 reference