Roughing up Smoothened: chemical modulators of hedgehog signaling (Q24794912)

6 July 2017

9 references

31 July 2019

17 September 2019

11 December 2019

15 December 2019

22 December 2019

23 December 2019

26 August 2020

10 September 2020

17 July 2021

Roughing up Smoothened: chemical modulators of hedgehog signaling (English)

1 reference

6 July 2017

cell surface receptor

1 reference

PubMed

G protein-coupled receptor

31 July 2019

heterocyclic compound

1 reference

17 September 2019

1 reference

11 December 2019

1 reference

15 December 2019

1 reference

22 December 2019

1 reference

23 December 2019

1 reference

26 August 2020

1 reference

10 September 2020

1 reference

17 July 2021

Randall W King

1

1 reference

PubMed ID

12437769

6 July 2017

language of work or name

English

0 references

publication date

6 November 2002

10 references

6 July 2017

31 July 2019

17 September 2019

11 December 2019

15 December 2019

22 December 2019

23 December 2019

26 August 2020

10 September 2020

17 July 2021

10 references

6 July 2017

31 July 2019

17 September 2019

11 December 2019

15 December 2019

22 December 2019

23 December 2019

26 August 2020

10 September 2020

17 July 2021

1

1 reference

6 July 2017

8

1 reference

6 July 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1186/1475-4924-1-8

6 July 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1475-4924-1-8

cites work

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Small molecule modulation of Smoothened activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Patched acts catalytically to suppress the activity of Smoothened

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Hedgehog signaling in animal development: paradigms and principles

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Mutations affecting segment number and polarity in Drosophila

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Chemical genetics: ligand-based discovery of gene function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Chemical genetics: exploring and controlling cellular processes with chemical probes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Teratogen-mediated inhibition of target tissue response to Shh signaling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137068

Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12437769

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Towards a pharmacological genetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12437769

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1475-4924-1-8

1 reference

PubMed ID

12437769

Dimensions Publication ID

6 July 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1475-4924-1-8

PMCID

137068

1 reference

6 July 2017

1 reference

PubMed ID

12437769