Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders (Q26741300)

Clinical and translational medicine

Europe PubMed Central

title

Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders (English)

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author name string

Sarika Srivastava

series ordinal

1

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language of work or name

English

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publication date

December 2016

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published in

1 reference

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

volume

5

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issue

1

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page(s)

25

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cites work

1 reference

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Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss

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The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions

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Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

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Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

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Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

7 April 2017

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

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ROS function in redox signaling and oxidative stress

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

7 April 2017

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SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity

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Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies

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Tumour-suppressive function of SIRT4 in human colorectal cancer

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Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer's Disease

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NAD⁺ metabolism: a therapeutic target for age-related metabolic disease

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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

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Exploring the therapeutic space around NAD+.

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Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

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Mitochondrial protein acetylation regulates metabolism

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The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

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Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

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PARP-2 regulates SIRT1 expression and whole-body energy expenditure

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

28 September 2017

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.

28 September 2017

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28 September 2017

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CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions

28 September 2017

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Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease

28 September 2017

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SirT1 gain of function increases energy efficiency and prevents diabetes in mice

28 September 2017

1 reference

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

28 September 2017

1 reference

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Sirt1 protects against high-fat diet-induced metabolic damage

28 September 2017

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

28 September 2017

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Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

28 September 2017

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Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

28 September 2017

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Mitochondrial-nuclear communications

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28 September 2017

Mitochondrial disease

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

28 September 2017

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The epidemiology of mitochondrial disorders--past, present and future

28 September 2017

1 reference

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Pellagra: dermatitis, dementia, and diarrhea

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Nuclear activators and coactivators in mammalian mitochondrial biogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Poly(ADP-ribose) in the cellular response to DNA damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

The Involvement of Poly(ADP-ribose) Polymerase in the Degradation of NAD Caused by gamma-Radiation and N-Methyl-N-Nitrosourea

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Turnover of nicotinamide adenine dinucleotide in cultures of human cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Pyridine nucleotide metabolism in mitotic cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Tissue-specific regulation of SIRT1 by calorie restriction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40169-016-0104-7

Altered expression of SIRT gene family in head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40169-016-0104-7

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40169-016-0104-7

Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1-42)-induced rat model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS40169-016-0104-7

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4963347

Mitochondrial disease criteria: Diagnostic applications in children

28 November 2018

1 reference

12 December 2020

Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis

1 reference

12 December 2020

Metabolic Effects of Nicotinamide Administration in Rats

1 reference

12 December 2020

Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes

1 reference

12 December 2020

Rat liver mitochondria can synthesize nicotinamide adenine dinucleotide from nicotinamide mononucleotide and ATP via a putative matrix nicotinamide mononucleotide adenylyltransferase

1 reference

12 December 2020

Mechanisms of glycolysis and fermentation

1 reference

12 December 2020

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

1 reference

https://api.crossref.org/works/10.1186%2FS40169-016-0104-7

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1186/S40169-016-0104-7

1 reference

Dimensions Publication ID

1037421047

0 references

1 reference

1 reference

PubMed publication ID

27465020

1 reference