Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy (Q26742060)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27447618%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

review article

2 references

10 July 2020

Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy (English)

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19 March 2020

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mesenchymal stem cell

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15 September 2019

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12 October 2019

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10 July 2020

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19 March 2020

Claudia Giachino

3

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author name string

Emanuela Vitale

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2

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publication date

19 July 2016

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19 March 2020

10 July 2020

International Journal of Molecular Sciences

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25 June 2019

15 September 2019

12 October 2019

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Creative Commons Attribution

19 March 2020

page(s)

1164

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copyright license

4 references

25 June 2019

15 September 2019

12 October 2019

10 July 2020

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7 April 2017

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7 April 2017

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Chemokine signaling via the CXCR2 receptor reinforces senescence

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Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin

7 April 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

7 April 2017

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Telomeres shorten during ageing of human fibroblasts

7 April 2017

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The senescence-associated secretory phenotype: the dark side of tumor suppression

7 April 2017

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

7 April 2017

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7 April 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

7 April 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

7 April 2017

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A DNA damage checkpoint response in telomere-initiated senescence

7 April 2017

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DNA damage foci at dysfunctional telomeres

7 April 2017

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Rapamycin reverses the senescent phenotype and improves immunoregulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway

7 April 2017

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Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells

28 September 2017

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A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome

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Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells.

28 September 2017

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28 September 2017

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IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Different facets of aging in human mesenchymal stem cells

28 September 2017

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28 September 2017

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28 September 2017

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Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions

28 September 2017

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Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3

28 September 2017

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DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

28 September 2017

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Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Control of senescence by CXCR2 and its ligands

28 September 2017

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Gene expression profiling of human mesenchymal stem cells for identification of novel markers in early- and late-stage cell culture

28 September 2017

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Long-term in vitro expansion alters the biology of adult mesenchymal stem cells

28 September 2017

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Replicative senescence of mesenchymal stem cells: a continuous and organized process

28 September 2017

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28 September 2017

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Mesenchymal stem cell preparations--comparing apples and oranges

28 September 2017

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Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

28 September 2017

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Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

28 September 2017

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The sensitivity of human mesenchymal stem cells to ionizing radiation

28 September 2017

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Differential damage and recovery of human mesenchymal stem cells after exposure to chemotherapeutic agents.

28 September 2017

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Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

28 September 2017

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Phosphatases in cell-matrix adhesion and migration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Reversal of human cellular senescence: roles of the p53 and p16 pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Coordinated regulation of life and death by RB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Multiple roles of the tumor suppressor p53.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Circulating cell adhesion molecules and death in patients with coronary artery disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

From cells to organisms: can we learn about aging from cells in culture?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

28 September 2017

Telomerase and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Senescence of human fibroblasts induced by oncogenic Raf.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Levels of soluble VCAM-1, soluble ICAM-1, and soluble E-selectin during disease exacerbations in patients with systemic lupus erythematosus (SLE); a long term prospective study

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Importance of serum source for the in vitro replicative senescence of human bone marrow derived mesenchymal stem cells.

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Differential effects of x-rays and high-energy 56Fe ions on human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Gamma radiation induces senescence in human adult mesenchymal stem cells from bone marrow and periodontal ligaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Proteomic and metabolomic analysis of H2O2-induced premature senescent human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Coevolution of cancer and stromal cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Mesenchymal stem cell-secreted soluble signaling molecules potentiate tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Senescent mesenchymal stem cells promote colorectal cancer cells growth via galectin-3 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Human multipotent stromal cells undergo sharp transition from division to development in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Accelerated growth and prolonged lifespan of adipose tissue-derived human mesenchymal stem cells in a medium using reduced calcium and antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS17071164

Mitoxantrone ability to induce premature senescence in human dental pulp stem cells and human dermal fibroblasts

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4964536

Differentiation-related response to DNA breaks in human mesenchymal stem cells

28 November 2018

1 reference

12 December 2020

Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage

1 reference

12 December 2020

Dual expression of hTERT and VEGF prolongs life span and enhances angiogenic ability of aged BMSCs

1 reference

12 December 2020

Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis

1 reference

12 December 2020

Two steps to functional mesenchymal stromal cells for clinical application

1 reference

12 December 2020

Mesenchymal stem cells cultured under hypoxia escape from senescence via down-regulation of p16 and extracellular signal regulated kinase

1 reference

12 December 2020

Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes

1 reference

12 December 2020

Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan

1 reference

12 December 2020

Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture

1 reference

12 December 2020

Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts

1 reference

12 December 2020

Evidences for correlation between the reduced VCAM-1 expression and hyaluronan synthesis during cellular senescence of human mesenchymal stem cells

1 reference

12 December 2020

Monitoring of cellular senescence by DNA-methylation at specific CpG sites

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS17071164

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27447618%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27447618%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

27447618

2 references