Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer (Q26765241)

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Language	Label	Description	Also known as
English	Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer	scientific article

Statements

scholarly article

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1 reference

31 October 2020

Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer (English)

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pancreatic neoplasm

1 reference

31 October 2020

early detection of cancer

1 reference

31 October 2020

tumor biomarkers

1 reference

7 August 2019

1 reference

based on heuristic

inferred from title

pancreatic cancer

1 reference

based on heuristic

inferred from title

intraepithelial neoplasia

1 reference

based on heuristic

inferred from title

author name string

Junli Guo

1

0 references

Keping Xie

2

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Shaojiang Zheng

3

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language of work or name

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publication date

28 January 2016

6 references

21 March 2019

24 March 2019

3 April 2019

19 June 2019

7 August 2019

31 October 2020

International Journal of Biological Sciences

6 references

21 March 2019

24 March 2019

3 April 2019

19 June 2019

7 August 2019

31 October 2020

12

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292-301

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3

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

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7 April 2017

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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7 April 2017

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets

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7 April 2017

Genetic alterations in pancreatic carcinoma

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7 April 2017

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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7 April 2017

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

1 reference

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7 April 2017

DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

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7 April 2017

Cancer statistics, 2013

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7 April 2017

Oncomirs - microRNAs with a role in cancer

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7 April 2017

MicroRNAs: genomics, biogenesis, mechanism, and function

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7 April 2017

Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes

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7 April 2017

Targeted destruction of the orchestration of the pancreatic stroma and tumor cells in pancreatic cancer cases: molecular basis for therapeutic implications

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7 April 2017

The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families

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7 April 2017

Sox17 regulates organ lineage segregation of ventral foregut progenitor cells

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7 April 2017

Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin

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7 April 2017

Cancer genes and the pathways they control

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7 April 2017

Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis

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7 April 2017

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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7 April 2017

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

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7 April 2017

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

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7 April 2017

EMT and dissemination precede pancreatic tumor formation

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7 April 2017

PARP inhibition: PARP1 and beyond

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7 April 2017

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group

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7 April 2017

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

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7 April 2017

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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7 April 2017

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 April 2017

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

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28 September 2017

Pancreatic cancer stromal biology and therapy

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28 September 2017

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

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28 September 2017

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

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28 September 2017

Trapping Poly(ADP-Ribose) Polymerase

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28 September 2017

Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography.

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28 September 2017

A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer

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28 September 2017

Pancreatic cancer stroma: friend or foe?

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28 September 2017

New PARP targets for cancer therapy

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28 September 2017

Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells

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28 September 2017

A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma

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28 September 2017

Dragging ras back in the ring

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28 September 2017

Recent treatment advances and novel therapies in pancreas cancer: a review

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28 September 2017

The roles of FOXM1 in pancreatic stem cells and carcinogenesis

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28 September 2017

The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models

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28 September 2017

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28 September 2017

Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas

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28 September 2017

New biomarkers and targets in pancreatic cancer and their application to treatment

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28 September 2017

Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologies

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28 September 2017

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28 September 2017

Current knowledge on pancreatic cancer

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28 September 2017

Targeting EGFR in pancreatic cancer treatment.

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28 September 2017

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

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28 September 2017

A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis

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28 September 2017

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

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28 September 2017

Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis

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28 September 2017

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28 September 2017

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28 September 2017

Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

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28 September 2017

Loss of heterozygosity status of D9S105 marker is associated with downregulation of Krüppel-like factor 4 expression in pancreatic ductal adenocarcinoma and pancreatic intraepithelial lesions

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28 September 2017

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28 September 2017

Role of pancreatic stellate cells in pancreatic cancer metastasis.

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28 September 2017

Pancreatic intraepithelial neoplasia-can we detect early pancreatic cancer?

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28 September 2017

KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer

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28 September 2017

MicroRNA-21 is induced early in pancreatic ductal adenocarcinoma precursor lesions

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28 September 2017

Genetic alterations in precancerous pancreatic lesions and their clinical implications

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28 September 2017

Pancreatic intraepithelial neoplasia and pancreatic tumorigenesis: of mice and men.

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28 September 2017

Co-evolution of tumor cells and their microenvironment

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28 September 2017

Pancreatic carcinogenesis

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28 September 2017

Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs)

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28 September 2017

Cancer-associated stromal fibroblasts promote pancreatic tumor progression

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28 September 2017

Pancreatic cancer.

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28 September 2017

Identifying molecular markers for the early detection of pancreatic neoplasia

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28 September 2017

Back to the future: COX-2 inhibitors for chemoprevention and cancer therapy

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28 September 2017

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28 September 2017

Mucin expression profile in pancreatic cancer and the precursor lesions

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28 September 2017

Molecular genetics of pancreatic intraepithelial neoplasia

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28 September 2017

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28 September 2017

Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer.

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28 September 2017

Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators

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28 September 2017

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28 September 2017

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28 September 2017

Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia

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28 September 2017

Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas

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28 September 2017

Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma.

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28 September 2017

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

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28 September 2017

BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications

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28 September 2017

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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28 September 2017

Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas

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28 September 2017

Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival

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28 September 2017

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions

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28 September 2017

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

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28 September 2017

K-ras mutation and pancreatic adenocarcinoma

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28 September 2017

DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer

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31 May 2018

Identification and manipulation of biliary metaplasia in pancreatic tumors.

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31 May 2018

Molecular pathways: context-dependent approaches to Notch targeting as cancer therapy

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31 May 2018

Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

31 May 2018

Expression of MUC apomucins in normal pancreas and pancreatic tumours.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

31 May 2018

K-ras mutations in pancreatic ductal proliferative lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

31 May 2018

Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

28 November 2018

PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

28 November 2018

Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

28 November 2018

Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

28 November 2018

Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

28 November 2018

Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4753158

28 November 2018

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term follow-up of patients with a clinically benign extrahepatic biliary stenosis and K-ras mutation in endobiliary brush cytology

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor induces cyclin D1 in human pancreatic carcinoma: evidence for a cyclin D1-dependent cell cycle progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle control and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Met is a marker of pancreatic cancer stem cells and therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MUC4 expression increases progressively in pancreatic intraepithelial neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem cells: an evolving concept

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26929736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.7150/IJBS.14995

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