Advances in therapeutic CRISPR/Cas9 genome editing (Q26782706)

RNA-guided genetic silencing systems in bacteria and archaea

PubMed

volume

168

0 references

page(s)

15-21

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

RNA-guided human genome engineering via Cas9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Non-homologous end joining as a mechanism of DNA repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

TALENs: a widely applicable technology for targeted genome editing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Genome editing with engineered zinc finger nucleases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Multiplex genome engineering using CRISPR/Cas systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Correction of a genetic disease in mouse via use of CRISPR-Cas9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Ethics of embryo editing divides scientists.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Don’t edit the human germ line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

State-of-the-art gene-based therapies: the road ahead

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

In vivo genome editing using Staphylococcus aureus Cas9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Fanconi anemia gene editing by the CRISPR/Cas9 system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Precision genome engineering with programmable DNA-nicking enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Long-term culture of genome-stable bipotent stem cells from adult human liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008

Somatic coding mutations in human induced pluripotent stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2015.09.008