Molecular and cellular insights into T cell exhaustion (Q26800047)

Nature Reviews Immunology

Europe PubMed Central

title

Molecular and cellular insights into T cell exhaustion (English)

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1 reference

E John Wherry

1

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Makoto Kurachi

series ordinal

2

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language of work or name

English

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publication date

August 2015

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published in

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volume

15

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page(s)

486-99

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issue

8

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cites work

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Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcγR.

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IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

28 September 2017

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PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

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The integration of T cell migration, differentiation and function

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Persistent LCMV infection is controlled by blockade of type I interferon signaling

28 September 2017

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Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

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PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

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28 September 2017

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Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.

28 September 2017

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Infected CD8α- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection

28 September 2017

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Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

28 September 2017

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

28 September 2017

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TGF-β blockade does not improve control of an established persistent viral infection

28 September 2017

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28 September 2017

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CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion

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28 September 2017

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Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

28 September 2017

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Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection

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Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration

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Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection

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Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.

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4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection

28 September 2017

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Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells

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Immunotherapeutic effects of IL-7 during a chronic viral infection in mice

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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

28 September 2017

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Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults

28 September 2017

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Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

28 September 2017

1 reference

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Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

28 September 2017

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Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

28 September 2017

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Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients

28 September 2017

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Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1

28 September 2017

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

28 September 2017

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Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection

28 September 2017

1 reference

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Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation

28 September 2017

1 reference

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Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

28 September 2017

1 reference

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Inflammatory cytokines as a third signal for T cell activation

28 September 2017

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Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency

28 September 2017

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Hepatitis C virus-induced cryoglobulinemia

28 September 2017

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Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

28 September 2017

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Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion

28 September 2017

1 reference

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Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells

28 September 2017

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PD-1 signaling in primary T cells

28 September 2017

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IL-21 is required to control chronic viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Regulatory T cells in the control of host-microorganism interactions (*).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

NFATc1 regulates PD-1 expression upon T cell activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Resolution of a chronic viral infection after interleukin-10 receptor blockade

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Immune control of herpes simplex virus during latency

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Cytokine control of memory T-cell development and survival

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Bystander chronic infection negatively impacts development of CD8(+) T cell memory.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Blockade of chronic type I interferon signaling to control persistent LCMV infection

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

A vital role for interleukin-21 in the control of a chronic viral infection

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Role of thymic output in regulating CD8 T-cell homeostasis during acute and chronic viral infection.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcγR or complement

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

The role of secondary lymphatic tissue in immune deficiency of HIV infection.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

IL-15-independent proliferative renewal of memory CD8+ T cells in latent gammaherpesvirus infection.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4889009

The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection

28 November 2018

1 reference

Longitudinal assessment of changes in HIV-specific effector activity in HIV-infected patients starting highly active antiretroviral therapy in primary infection

31 March 2020

1 reference

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

31 March 2020

1 reference

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

31 March 2020

1 reference

Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI3862

1 reference

Dimensions Publication ID

1230839

1019011944

0 references

1230839

1 reference

1 reference

1 reference