Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux (Q26820876)

John M. Stafford

series ordinal

2

1 reference

Owen P. McGuinness

series ordinal

3

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language of work or name

1 reference

25 July 2014

1 reference

Journal of Biological Chemistry

published in

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volume

289

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issue

30

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page(s)

20462-9

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Glucose-6-phosphatase deficiency

cites work

1 reference

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Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

7 April 2017

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Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

7 April 2017

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FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

7 April 2017

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Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

7 April 2017

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

7 April 2017

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Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein

7 April 2017

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Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

7 April 2017

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Liver but not adipose tissue is responsive to the pattern of enteral feeding

7 April 2017

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Evidence for central regulation of glucose metabolism

28 September 2017

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Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes

28 September 2017

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Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance

28 September 2017

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One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDL-triglyceride secretion in overweight and obese men

28 September 2017

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De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

28 September 2017

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The role of the carbohydrate response element-binding protein in male fructose-fed rats

28 September 2017

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Transcriptional regulation of pyruvate dehydrogenase kinase

28 September 2017

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Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance

28 September 2017

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Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia

28 September 2017

1 reference

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Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2

28 September 2017

1 reference

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Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression

28 September 2017

1 reference

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The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

28 September 2017

1 reference

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Multiorgan insulin sensitivity in lean and obese subjects.

28 September 2017

1 reference

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Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Postprandial metabolism of meal triglyceride in humans

28 September 2017

1 reference

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Glycogen and its metabolism: some new developments and old themes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease.

28 September 2017

1 reference

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Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes

28 September 2017

1 reference

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Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women

28 September 2017

1 reference

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Increased VLDL-triglyceride secretion precedes impaired control of endogenous glucose production in obese, normoglycemic men.

28 September 2017

1 reference

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Defective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in zucker diabetic fatty rats

28 September 2017

1 reference

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Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors.

28 September 2017

1 reference

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Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

28 September 2017

1 reference

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New lipid modulating drugs: the role of microsomal transport protein inhibitors

28 September 2017

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A dual sugar challenge test for lipogenic sensitivity to dietary fructose

28 September 2017

1 reference

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Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Hypoglycemia in type 1 diabetes mellitus

28 September 2017

1 reference

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Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy

28 September 2017

1 reference

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A retrospective review of the roles of multifunctional glucose-6-phosphatase in blood glucose homeostasis: Genesis of the tuning/retuning hypothesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Genetic control of de novo lipogenesis: role in diet-induced obesity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

28 September 2017

1 reference

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Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

28 September 2017

1 reference

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Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

28 September 2017

1 reference

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Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4110258

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

28 September 2017

1 reference

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Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats

28 September 2017

1 reference

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Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors

28 September 2017

1 reference

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ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice

28 September 2017

1 reference

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Selective versus total insulin resistance: a pathogenic paradox

28 September 2017

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Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.

28 September 2017

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Canine diabetes mellitus: from phenotype to genotype.

28 September 2017

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Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis

28 September 2017

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Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

28 September 2017

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Effects of type 2 diabetes on the regulation of hepatic glucose metabolism

28 September 2017

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Hypoglycemia in type 2 diabetes

28 September 2017

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Regulation of hepatic and peripheral glucose disposal

28 September 2017

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Effects of fructose on hepatic glucose metabolism

28 September 2017

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Pathogenesis of feline diabetes mellitus

28 September 2017

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Insulin-regulated gene expression

28 September 2017

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Metabolic complications of obesity

28 September 2017

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

28 September 2017

1 reference

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Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

28 September 2017

1 reference

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De novo lipogenesis in humans: metabolic and regulatory aspects

28 September 2017

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The cellular and molecular mechanisms of diabetic complications

28 September 2017

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Short-term control of glucokinase activity: role of a regulatory protein

28 September 2017

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Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

28 September 2017

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Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans

28 September 2017

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Sources of carbon for hepatic glycogen synthesis in the conscious dog

28 September 2017

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Regulation of net hepatic glucose uptake in vivo

28 September 2017

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Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans

28 September 2017

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Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats

28 September 2017

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Transport of Very Low Density Lipoprotein Triglycerides in Varying Degrees of Obesity and Hypertriglyceridemia

28 September 2017

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Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

28 September 2017

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Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases

28 September 2017

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Effects of type 2 diabetes on insulin secretion, insulin action, glucose effectiveness, and postprandial glucose metabolism

31 May 2018

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Fatty acid regulation of very low density lipoprotein production

31 May 2018

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Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis

31 May 2018

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Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role of increased rates of gluconeogenesis.

21 January 2018

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Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans

21 January 2018

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Elevated free fatty acids impair glucose metabolism in women: decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia

21 January 2018

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Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes

21 January 2018

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Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ

21 January 2018

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Impact of portal glucose delivery on glucose metabolism in conscious, unrestrained mice.

21 January 2018

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Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a.

21 January 2018

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Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states

21 January 2018

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Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men.

21 January 2018

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Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans

21 January 2018

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Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification

21 January 2018

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A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes

21 January 2018

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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

21 January 2018

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VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity.

21 January 2018

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Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy

21 January 2018

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Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats

21 January 2018

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"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

21 January 2018

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21 January 2018

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Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats

21 January 2018

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12 December 2020

Time trends and risk factors for diabetes mellitus in cats presented to veterinary teaching hospitals

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12 December 2020

Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas

1 reference

12 December 2020

Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats

1 reference

12 December 2020

Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion

1 reference

12 December 2020