The role of APP and BACE1 trafficking in APP processing and amyloid-β generation (Q26825686)

Crossref

language of work or name

1 reference

2013

1 reference

Alzheimers Research & Therapy

published in

1 reference

Crossref

volume

5

1 reference

issue

5

1 reference

page(s)

46

1 reference

Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

7 April 2017

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

7 April 2017

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

7 April 2017

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Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

7 April 2017

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

7 April 2017

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Gamma-secretase complex assembly within the early secretory pathway

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

7 April 2017

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

7 April 2017

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The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

7 April 2017

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Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.

7 April 2017

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ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

28 September 2017

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Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein

28 September 2017

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Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.

28 September 2017

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Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

28 September 2017

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

28 September 2017

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Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

28 September 2017

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

28 September 2017

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Alzheimer's disease beta-amyloid peptides are released in association with exosomes

28 September 2017

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Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

28 September 2017

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Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription

28 September 2017

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GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

28 September 2017

1 reference

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Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

28 September 2017

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BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

28 September 2017

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Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

28 September 2017

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Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

28 September 2017

1 reference

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Degradation of BACE by the ubiquitin-proteasome pathway

28 September 2017

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

28 September 2017

1 reference

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

28 September 2017

1 reference

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

28 September 2017

1 reference

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

28 September 2017

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Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

28 September 2017

1 reference

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Maturation and pro-peptide cleavage of beta-secretase

28 September 2017

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Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

28 September 2017

1 reference

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

28 September 2017

1 reference

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Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

28 September 2017

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The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

28 September 2017

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Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

28 September 2017

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

28 September 2017

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

28 September 2017

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Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

28 September 2017

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

28 September 2017

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

28 September 2017

1 reference

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

28 September 2017

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Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes

28 September 2017

1 reference

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Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles

31 May 2018

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Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

31 May 2018

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

31 May 2018

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

31 May 2018

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Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis

31 May 2018

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Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

31 May 2018

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

31 May 2018

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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

31 May 2018

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

31 May 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

31 May 2018

1 reference

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Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

31 May 2018

1 reference

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Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.

28 November 2018

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Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.

28 November 2018

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GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

28 November 2018

1 reference

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Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

28 November 2018

1 reference

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

28 November 2018

1 reference

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Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

28 November 2018

1 reference

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The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

28 November 2018

1 reference

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Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

28 November 2018

1 reference

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Processing of beta-secretase by furin and other members of the proprotein convertase family

28 November 2018

1 reference

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Effects of PS1 deficiency on membrane protein trafficking in neurons

28 November 2018

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Generation and regulation of beta-amyloid peptide variants by neurons.

28 November 2018

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An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde".

28 November 2018

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

28 November 2018

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Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

28 November 2018

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12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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12 December 2020

2011 Alzheimer's disease facts and figures

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12 December 2020

Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain

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12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

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12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization

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Subcellular distribution and turnover of presenilins in transfected cells

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Dimensions Publication ID

Identifiers

DOI

10.1186/ALZRT211

0 references

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/alzrt211

1 reference

PubMed publication ID

24103387

1 reference