Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes (Q42162160)

17 October 2017

Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes (English)

1 reference

17 October 2017

5

Judith Klumperman

0 references

Viola Oorschot

3

object named as

Viola M J Oorschot

0 references

Dennis J. Selkoe

4

object named as

Dennis J Selkoe

1 reference

17 October 2017

Marloes Réchards

1

1 reference

PubMed ID

12839498

17 October 2017

Weiming Xia

2

1 reference

PubMed ID

12839498

17 October 2017

Viola M J Oorschot

3

1 reference

17 October 2017

1 August 2003

1 reference

17 October 2017

1 reference

17 October 2017

4

1 reference

17 October 2017

8

1 reference

17 October 2017

553-565

1 reference

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

17 October 2017

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilins: genes for life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilins: molecular switches between proteolysis and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Sorting and retrieval between the endoplasmic reticulum and Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

SNARE membrane trafficking dynamics in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Transport between ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Alzheimer's disease. Closing in on gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Mutant presenilin 1 increases the levels of Alzheimer amyloid beta-peptide Abeta42 in late compartments of the constitutive secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

Alzheimer's disease: genes, proteins, and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2003.T01-1-00114.X

7 January 2021

10.1034/J.1600-0854.2003.T01-1-00114.X

Identifiers

DOI

1 reference

17 October 2017

1 reference

PubMed ID

12839498