Prospects for nucleic acid-based therapeutics against hepatitis C virus (Q26852368)

Crossref

language of work or name

1 reference

21 December 2013

1 reference

World Journal of Gastroenterology

published in

1 reference

volume

19

1 reference

issue

47

1 reference

page(s)

8949-62

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Inhibition of microRNA function by antimiR oligonucleotides

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Investigating a New Generation of Ribozymes in Order to Target HCV

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A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

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Small Interfering RNA Targeted to Hepatitis C Virus 5' Nontranslated Region Exerts Potent Antiviral Effect

7 April 2017

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High-Affinity Aptamers to Subtype 3a Hepatitis C Virus Polymerase Display Genotypic Specificity

7 April 2017

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Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region

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Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

7 April 2017

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Interference of hepatitis C virus RNA replication by short interfering RNAs

7 April 2017

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Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

7 April 2017

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Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7

7 April 2017

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Silencing of microRNAs in vivo with 'antagomirs'

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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

7 April 2017

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

7 April 2017

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7 April 2017

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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

7 April 2017

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A system for stable expression of short interfering RNAs in mammalian cells

7 April 2017

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Hepatitis C virus infection

7 April 2017

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

7 April 2017

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Role for a bidentate ribonuclease in the initiation step of RNA interference

7 April 2017

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RNA interference is mediated by 21- and 22-nucleotide RNAs

7 April 2017

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Efficient initiation of HCV RNA replication in cell culture

7 April 2017

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

7 April 2017

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

7 April 2017

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

7 April 2017

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In vitro selection of RNA molecules that bind specific ligands

7 April 2017

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

7 April 2017

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

7 April 2017

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Molecular mechanisms of RNA interference

7 April 2017

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Strategies for silencing human disease using RNA interference

7 April 2017

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RNA plasticity and selectivity applicable to therapeutics and novel biosensor development

7 April 2017

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Ribozymes, riboswitches and beyond: regulation of gene expression without proteins

7 April 2017

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Treatment of HCV infection by targeting microRNA

7 April 2017

1 reference

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

7 April 2017

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

7 April 2017

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

7 April 2017

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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide

7 April 2017

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Replication of hepatitis C virus

7 April 2017

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Completion of the entire hepatitis C virus life cycle in genetically humanized mice

7 April 2017

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Inhibition of hepatitis C virus infection by DNA aptamer against envelope protein

28 September 2017

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The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

28 September 2017

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Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase

28 September 2017

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RNA aptamer-mediated interference of HCV replication by targeting the CRE-5BSL3.2 domain

28 September 2017

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Therapeutic potential of RNA interference: a new molecular approach to antiviral treatment for hepatitis C.

28 September 2017

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Replication of hepatitis C virus genotype 3a in cultured cells

28 September 2017

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MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

28 September 2017

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Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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RNA therapeutics: beyond RNA interference and antisense oligonucleotides

28 September 2017

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28 September 2017

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The many faces of the hairpin ribozyme: structural and functional variants of a small catalytic RNA.

28 September 2017

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HCV entry receptors as potential targets for siRNA-based inhibition of HCV.

28 September 2017

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Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV.

28 September 2017

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Inhibition of full length hepatitis C virus particles of 1a genotype through small interference RNA

28 September 2017

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Post-transcriptional inhibition of hepatitis C virus replication through small interference RNA.

28 September 2017

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MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.

28 September 2017

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Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses

28 September 2017

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Inhibition of hepatitis C virus gene expression by adenoviral vectors encoding antisense RNA in vitro and in vivo

28 September 2017

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Inhibition of hepatitis C virus replication using adeno-associated virus vector delivery of an exogenous anti-hepatitis C virus microRNA cluster.

28 September 2017

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Suppression of hepatitis C virus genome replication in cells with RNA-cleaving DNA enzymes and short-hairpin RNA.

28 September 2017

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Therapeutic applications of ribozymes and riboswitches

28 September 2017

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RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

28 September 2017

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Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs).

28 September 2017

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RNAi as a new therapeutic strategy against HCV.

28 September 2017

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MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

28 September 2017

1 reference

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Drug targets in cytomegalovirus infection

28 September 2017

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Site-specific cleavage of HCV genomic RNA and its cloned core and NS5B genes by DNAzyme

28 September 2017

1 reference

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Inhibition of HCV replication by small interfering RNA.

28 September 2017

1 reference

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Sequence-specific cleavage of hepatitis C virus RNA by DNAzymes: inhibition of viral RNA translation and replication

28 September 2017

1 reference

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Therapeutic applications of aptamers

28 September 2017

1 reference

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Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.

28 September 2017

1 reference

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Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.

28 September 2017

1 reference

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Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.

28 September 2017

1 reference

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Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma

28 September 2017

1 reference

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Development of ribozyme-based gene-inactivations; the example of the hepatitis delta virus ribozyme

28 September 2017

1 reference

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Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology

28 September 2017

1 reference

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Gene therapy progress and prospects: RNA aptamers

28 September 2017

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Inhibition of hepatitis C virus replication and expression by small interfering RNA targeting host cellular genes

28 September 2017

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Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice

28 September 2017

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Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.

28 September 2017

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Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection

28 September 2017

1 reference

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RNA interference effectively inhibits mRNA accumulation and protein expression of hepatitis C virus core and E2 genes in human cells

28 September 2017

1 reference

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Treating viral hepatitis C: efficacy, side effects, and complications

28 September 2017

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Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Antisense oligonucleotides: from design to therapeutic application

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Cleavage of intracellular hepatitis C RNA in the virus core protein coding region by deoxyribozymes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Hairpin ribozymes in combination with siRNAs against highly conserved hepatitis C virus sequence inhibit RNA replication and protein translation from hepatitis C virus subgenomic replicons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Unlocking the potential of the human genome with RNA interference

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Improving the efficiency of RNA interference in mammals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Inducible, reversible, and stable RNA interference in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Engineered catalytic RNA and DNA : new biochemical tools for drug discovery and design

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Ribozymes: recent advances in the development of RNA tools

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Inhibition of HCV NS3 protease by RNA aptamers in cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

28 September 2017

Ribozyme therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Activity of HDV ribozymes to trans-cleave HCV RNA

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

The therapeutic potential of ribozymes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

A potential therapeutic application of hairpin ribozymes: in vitro and in vivo studies of gene therapy for hepatitis C virus infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Cleavage of viral RNA and inhibition of viral translation by hepatitis C virus RNA-specific hammerhead ribozyme in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Emerging LDL therapies: Mipomersen-antisense oligonucleotide therapy in the management of hypercholesterolemia.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Hepatitis C virus replication-specific inhibition of microRNA activity with self-cleavable allosteric ribozyme

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Inhibition of hepatitis C virus gene expression by small interfering RNAs using a tri-cistronic full-length viral replicon and a transient mouse model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Intracellular-diced dsRNA has enhanced efficacy for silencing HCV RNA and overcomes variation in the viral genotype

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Functional characterization of the SOFA delta ribozyme

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Virological effects of ISIS 14803, an antisense oligonucleotide inhibitor of hepatitis C virus (HCV) internal ribosome entry site (IRES), on HCV IRES in chronic hepatitis C patients and examination of the potential role of primary and secondary HCV r

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Catalytic RNase P RNA from Synechocystis sp. cleaves the hepatitis C virus RNA near the AUG start codon

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

In vitro selection of RNA aptamers against the HCV NS3 helicase domain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Characterization of the structure and variability of an internal region of hepatitis C virus RNA for M1 RNA guide sequence ribozyme targeting.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Specific cleavage of hepatitis C virus RNA genome by human RNase P.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Pharmacokinetics and tissue distribution of a ribozyme directed against hepatitis C virus RNA following subcutaneous or intravenous administration in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Ribozyme gene therapy for hepatitis C virus infection

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

Selection of guide sequences that direct efficient cleavage of mRNA by human ribonuclease P.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870548

28 November 2018

Identifiers

DOI

10.3748/WJG.V19.I47.8949

0 references

1 reference

PubMed publication ID

24379620

1 reference