The regulation and deregulation of Wnt signaling by PARK genes in health and disease (Q26991986)

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27 February 2020

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8 October 2022

The regulation and deregulation of Wnt signaling by PARK genes in health and disease (English)

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25 April 2019

12 September 2019

1 reference

12 September 2019

1 reference

29 April 2021

1

1 reference

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27 February 2020

author name string

Kirsten Harvey

series ordinal

2

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9 October 2013

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Journal of Molecular Cell Biology

27 February 2020

1 February 2014

2 references

29 April 2021

8 October 2022

6 references

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12 September 2019

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6

2 references

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issue

1

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3-12

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Creative Commons Attribution 3.0 Unported

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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21 March 2017

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7 April 2017

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7 April 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease

28 September 2017

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Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for n

28 September 2017

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Role of GSK3 Signaling in Neuronal Morphogenesis

28 September 2017

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GSK-3: Functional Insights from Cell Biology and Animal Models

28 September 2017

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28 September 2017

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VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

28 September 2017

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LRRK2 Parkinson disease mutations enhance its microtubule association.

28 September 2017

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VPS35 mutations in Parkinson disease

28 September 2017

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A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression

28 September 2017

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28 September 2017

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LRRK2 signaling pathways: the key to unlocking neurodegeneration?

28 September 2017

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Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes

28 September 2017

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Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.

28 September 2017

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The Wnt /β-catenin signaling pathway in the adult neurogenesis

28 September 2017

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Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

28 September 2017

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

28 September 2017

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GSK3 signalling in neural development

28 September 2017

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Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

28 September 2017

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The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

28 September 2017

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Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

28 September 2017

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The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth.

28 September 2017

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Emerging roles of Wnts in the adult nervous system

28 September 2017

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LRRK2 in Parkinson's disease: genetic and clinical studies from patients

28 September 2017

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Wnt signaling in development and disease

28 September 2017

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Molecular pathogenesis of Parkinson disease: insights from genetic studies

28 September 2017

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Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

28 September 2017

1 reference

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

The genetics of Crohn's disease

28 September 2017

1 reference

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Xenopus Wntless and the retromer complex cooperate to regulate XWnt4 secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Genetic factors influencing age at onset in LRRK2-linked Parkinson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

The Roco protein family: a functional perspective

28 September 2017

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From 1997 to 2007: a decade journey through the H1 haplotype on 17q21 chromosome

28 September 2017

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The Wnt signaling pathway: aging gracefully as a protectionist?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Effects of gender on nigral gene expression and parkinson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Parkinsonism, Lrrk2 G2019S, and tau neuropathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Function of Wnts in dopaminergic neuron development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Wnt gradient formation requires retromer function in Wnt-producing cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Model-guided microarray implicates the retromer complex in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Nurr1 mutational screen in Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

An essay on the shaking palsy. 1817.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

L-dopa in parkinson's syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

LRRK2 I2020T mutation is associated with tau pathology

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

LRRK2 and human disease: a complicated question or a question of complexes?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

SNCA,MAPT, andGSK3Bin Parkinson disease: a gene-gene interaction study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

An alternatively spliced form of glycogen synthase kinase-3beta is targeted to growing neurites and growth cones.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

GSK3β polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation. Association with Parkinson disease, malignant melanoma and prevalence in ethnic groups in Israel.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4344548

Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24115276

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[Analysis of single nucleotide polymorphism rs415430 in the WNT3 gene in the Russian population with the Parkinson disease]

1 reference

https://pubmed.ncbi.nlm.nih.gov/24115276

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multisite phosphorylation of glycogen synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24115276

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/JMCB/MJT037

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24115276%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24115276%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

PubMed publication ID

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24115276%20AND%20SRC:MED&resulttype=core&format=json