Recognition of cytosolic DNA by cGAS and other STING-dependent sensors (Q27000358)

Katherine A. Fitzgerald

series ordinal

2

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language of work or name

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March 2014

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European Journal of Immunology

published in

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volume

44

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page(s)

634-40

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issue

3

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Cytosolic sensing of viruses

cites work

1 reference

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 March 2017

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Activation of STAT6 by STING is critical for antiviral innate immunity

21 March 2017

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STING is a direct innate immune sensor of cyclic di-GMP

21 March 2017

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

21 March 2017

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 March 2017

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

21 March 2017

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Pattern recognition receptors and inflammation

21 March 2017

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IFI16 as a negative regulator in the regulation of p53 and p21(Waf1)

21 March 2017

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Role of IFI16 in DNA damage and checkpoint

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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

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The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

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The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

21 March 2017

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 March 2017

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HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

21 March 2017

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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 March 2017

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Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 March 2017

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The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.

7 April 2017

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28 September 2017

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

28 September 2017

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

28 September 2017

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Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

28 September 2017

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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

28 September 2017

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

28 September 2017

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28 September 2017

Immune sensing of DNA

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Molecular basis of DNA recognition in the immune system

28 September 2017

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Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

28 September 2017

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Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

28 September 2017

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28 September 2017

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Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages

28 September 2017

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Cytosolic surveillance and antiviral immunity

28 September 2017

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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity

28 September 2017

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Regulation of the antimicrobial response by NLR proteins.

28 September 2017

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28 September 2017

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Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

28 September 2017

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Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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