Mendelian randomization: genetic anchors for causal inference in epidemiological studies (Q27002487)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

review article

0 references

title

Mendelian randomization: genetic anchors for causal inference in epidemiological studies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

biomedical investigative technique

10 March 2020

main subject

1 reference

19 September 2019

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Gibran Hemani

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

author name string

G. Davey Smith

series ordinal

1

1 reference

language of work or name

1 reference

4 July 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

published in

Human Molecular Genetics

3 references

19 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

volume

23

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

page(s)

R89-98

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

issue

R1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

10 March 2020

copyright license

1 reference

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

19 September 2019

0 references

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mendelian randomisation and causal inference in observational epidemiology

21 March 2017

1 reference

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Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Design, analysis and presentation of factorial randomised controlled trials

21 March 2017

1 reference

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Data dredging, bias, or confounding

21 March 2017

1 reference

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Perspective: Evolutionary developmental biology and the problem of variation

21 March 2017

1 reference

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Pleiotropy in complex traits: challenges and strategies

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

The fat mass- and obesity-associated locus and dietary intake in children

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Discovery and refinement of loci associated with lipid levels

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Common variants associated with plasma triglycerides and risk for coronary artery disease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approach

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Effects of torcetrapib in patients at high risk for coronary events

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Methodological challenges in mendelian randomization

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mendelian randomization of blood lipids for coronary heart disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Causal inference of gene regulation with subnetwork assembly from genetical genomics data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mining the human phenome using allelic scores that index biological intermediates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Calculating statistical power in Mendelian randomization studies.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Prenatal alcohol exposure and offspring cognition and school performance. A 'Mendelian randomization' natural experiment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

From promises to practical strategies in epigenetic epidemiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

The role of measurement error and misclassification in mediation analysis: mediation and measurement error

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Commentary: The seven plagues of epigenetic epidemiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mendelian randomization: application to cardiovascular disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mendelian randomization analysis of case-control data using structural mean models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

CAUSAL GRAPHICAL MODELS IN SYSTEMS GENETICS: A UNIFIED FRAMEWORK FOR JOINT INFERENCE OF CAUSAL NETWORK AND GENETIC ARCHITECTURE FOR CORRELATED PHENOTYPES

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

One hundred years of pleiotropy: a retrospective

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Genomic patterns of pleiotropy and the evolution of complexity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Usefulness of Mendelian randomization in observational epidemiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

How does body fat influence bone mass in childhood? A Mendelian randomization approach

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Assessing intrauterine influences on offspring health outcomes: can epidemiological studies yield robust findings?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Toward a molecular understanding of pleiotropy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Mendelian randomization: prospects, potentials, and limitations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Seven types of pleiotropy.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Pleiotropy revisited: molecular explanations of a classic concept

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Folate supplementation and cardiovascular disease

31 May 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

The impact of residual and unmeasured confounding in epidemiologic studies: a simulation study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case–Cohort Study, 1984–2002

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Pleiotropic scaling of gene effects and the 'cost of complexity'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Use of allele scores as instrumental variables for Mendelian randomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

What are the key arguments against uric acid as a true risk factor for hypertension?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Random allocation in observational data: how small but robust effects could facilitate hypothesis-free causal inference

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Misclassification of the mediator matters when estimating indirect effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Quantification of bias in direct effects estimates due to different types of measurement error in the mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU328

Causal relationship between body mass index and fetuin-A level in the asian population: a bidirectional Mendelian randomization study.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Negative control exposures in epidemiologic studies.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170722

Epidemiology--is it time to call it a day?

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25064373

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDU328

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25064373%20AND%20SRC:MED&resulttype=core&format=json