Current prospects and challenges for epilepsy gene therapy (Q27002627)

Crossref

Thomas J. McCown

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

June 2013

1 reference

published in

Experimental Neurology

1 reference

volume

244

1 reference

page(s)

27-35

1 reference

Vision 1 year after gene therapy for Leber's congenital amaurosis

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Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates

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Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors

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Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

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Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.

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Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus

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Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates.

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Knockdown and overexpression of NR1 modulates NMDA receptor function.

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Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons

28 September 2017

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Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model

28 September 2017

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When drugs and surgery don't work

28 September 2017

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Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP.

28 September 2017

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Self-complementary AAV vectors; advances and applications

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Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures

28 September 2017

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Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures

28 September 2017

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NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

28 September 2017

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AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method

28 September 2017

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An antigen-specific pathway for CD8 T cells across the blood-brain barrier

28 September 2017

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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

28 September 2017

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Seizure suppression by GDNF gene therapy in animal models of epilepsy

28 September 2017

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Angels and demons: neurotrophic factors and epilepsy.

28 September 2017

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Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo

28 September 2017

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Neuroprotection of adenoviral-vector-mediated GDNF expression against kainic-acid-induced excitotoxicity in the rat hippocampus

28 September 2017

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Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.

28 September 2017

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Astrocytic purinergic signaling coordinates synaptic networks

28 September 2017

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Genetically engineered cells with regulatable GABA production can affect afterdischarges and behavioral seizures after transplantation into the dentate gyrus

28 September 2017

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Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?

28 September 2017

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Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

28 September 2017

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Galanin acts as a neuroprotective factor to the hippocampus

28 September 2017

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Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

28 September 2017

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Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current

28 September 2017

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Presurgical evaluation and surgical treatment of medically refractory epilepsy

28 September 2017

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Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches

28 September 2017

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Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity

28 September 2017

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Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain

28 September 2017

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Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

28 September 2017

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The neurotrophin hypothesis for synaptic plasticity.

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28 September 2017

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Therapeutic potential of neurotrophic factors and neural stem cells against ischemic brain injury

28 September 2017

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Adeno-associated virus vectors: activity and applications in the CNS.

28 September 2017

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Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats

28 September 2017

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Dopaminergic neurons protected from degeneration by GDNF gene therapy

28 September 2017

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Some aspects of prognosis in the epilepsies: a review

28 September 2017

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Effects of neuropeptide Y on the electrical properties of neurons

28 September 2017

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Surgical treatment of the epilepsies: presurgical evaluation

28 September 2017

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Adenosine: a potential mediator of seizure arrest and postictal refractoriness

28 September 2017

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EEG and other early predictors of epilepsy remission: a community study

28 September 2017

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Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus.

28 September 2017

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Dystrophin immunity in Duchenne's muscular dystrophy.

31 May 2018

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Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC.

31 May 2018

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Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors.

31 May 2018

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Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice

31 May 2018

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Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice

31 May 2018

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Modulation of hippocampal excitability and seizures by galanin.

31 May 2018

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Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.

31 May 2018

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Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity

31 May 2018

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Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector

31 May 2018

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Neuropeptide Y inhibits potassium-stimulated glutamate release through Y2 receptors in rat hippocampal slices in vitro.

31 May 2018

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Adenosine modulation of amygdala kindling

31 May 2018

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Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.

31 May 2018

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Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.

28 November 2018

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Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus

28 November 2018

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Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors

28 November 2018

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Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

28 November 2018

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Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

28 November 2018

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Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo

28 November 2018

1 reference

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Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy.

28 November 2018

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Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice

28 November 2018

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Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity

28 November 2018

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Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats

28 November 2018

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Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

28 November 2018

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Transplants of cells engineered to produce GABA suppress spontaneous seizures

28 November 2018

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Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion

28 November 2018

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Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice

28 November 2018

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Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs.

28 November 2018

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Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats

28 November 2018

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Heightened seizure severity in somatostatin knockout mice

28 November 2018

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Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus.

28 November 2018

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Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy

28 November 2018

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Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

28 November 2018

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Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra

28 November 2018

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Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290712

Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290712

Autoradiographic distribution of 125I-galanin binding sites in the rat central nervous system

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290712

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

28 November 2018

1 reference

12 December 2020

Y1 and Y2 receptors for neuropeptide Y

1 reference

12 December 2020

The Human and Economic Burden of Epilepsy

1 reference

12 December 2020

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy

1 reference

12 December 2020

Lower plasma neuropeptide Y level in patients with atypical febrile convulsions

1 reference

12 December 2020

Autoradiographic quantitation and anatomical mapping of 125I-galanin binding sites in the rat central nervous system

1 reference

12 December 2020

Case 15-2009: a man with coma after cardiac arrest

1 reference

12 December 2020

10.1016/J.EXPNEUROL.2011.10.003

Identifiers

DOI

0 references

1 reference

PubMed publication ID

22008258

1 reference