Regulation of PP2A by Sphingolipid Metabolism and Signaling (Q27026038)

Crossref

Besim Ogretmen

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

2014

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published in

Frontiers in Oncology

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Crossref

volume

4

1 reference

page(s)

388

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Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET

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CIP2A inhibits PP2A in human malignancies

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

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Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

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The structural requirements for ceramide activation of serine-threonine protein phosphatases

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Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor

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Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia

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FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels

21 March 2017

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Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity

21 March 2017

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Expression and prognostic significance of CIP2A in cutaneous malignant melanoma

28 September 2017

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CIP2A influences survival in colon cancer and is critical for maintaining Myc expression

28 September 2017

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Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment

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CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasion

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Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

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Expression and biological role of CIP2A in human astrocytoma

28 September 2017

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Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

28 September 2017

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Phosphorylation of SET protein at Ser171 by protein kinase D2 diminishes its inhibitory effect on protein phosphatase 2A

28 September 2017

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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

28 September 2017

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Identification and characterization of protein phosphatase 2C activation by ceramide

28 September 2017

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28 September 2017

Sphingolipids in cancer

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Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity

28 September 2017

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SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target

28 September 2017

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Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.

28 September 2017

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Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers

28 September 2017

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Identification of distinct SET/TAF-Ibeta domains required for core histone binding and quantitative characterisation of the interaction

28 September 2017

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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

28 September 2017

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FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

28 September 2017

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Functional interaction of Aurora-A and PP2A during mitosis

28 September 2017

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

28 September 2017

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PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.

28 September 2017

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Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines.

28 September 2017

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Involvement of protein phosphatase 2A in interferon-alpha-2b-induced apoptosis in K562 human chronic myelogenous leukaemia cells.

28 September 2017

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Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells

28 September 2017

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Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

28 September 2017

1 reference

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Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation

28 September 2017

1 reference

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Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter

28 September 2017

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Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4295541

Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function

31 May 2018

1 reference

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Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects

31 May 2018

1 reference

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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

31 May 2018

1 reference

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Ceramide activates heterotrimeric protein phosphatase 2A.

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4295541

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

31 May 2018

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Over-expression of cancerous inhibitor of PP2A (CIP2A) in bone marrow cells from patients with a group of high-risk myelodysplastic syndromes.

31 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4295541

CIP2A expression and prognostic role in patients with esophageal adenocarcinoma

28 November 2018

1 reference

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CIP2A expression is associated with altered expression of epithelial-mesenchymal transition markers and predictive of poor prognosis in pancreatic ductal adenocarcinoma

28 November 2018

1 reference

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Clinical implications of CIP2A protein expression in breast cancer

28 November 2018

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Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease

28 November 2018

1 reference

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KIAA1524: A novel MLL translocation partner in acute myeloid leukemia.

28 November 2018

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SET complex in serous epithelial ovarian cancer

28 November 2018

1 reference

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Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4295541

Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.

28 November 2018

1 reference

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Coiled-coil structure-mediated dimerization of template activating factor-I is critical for its chromatin remodeling activity.

28 November 2018

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Functional domains of template-activating factor-I as a protein phosphatase 2A inhibitor

28 November 2018

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12 December 2020

Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements

1 reference

12 December 2020

H3K27 methylation and H3S28 phosphorylation-dependent transcriptional regulation by INHAT subunit SET/TAF-Iβ

1 reference

12 December 2020

pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer

1 reference

12 December 2020

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression

1 reference

12 December 2020

Programmed cell death induced by ceramide

1 reference

12 December 2020

Identifiers

DOI

10.3389/FONC.2014.00388

1 reference

4143073

4143073

1 reference

1 reference

1 reference