Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics (Q27489037)

4

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Jeremy Luban

object named as

Jeremy Luban

10

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Volker Lohmann

object named as

Volker Lohmann

9

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author name string

Artur Kaul

1

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Sarah Stauffer

2

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Carola Berger

3

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Jennifer Schmitt

5

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Stephanie Kallis

6

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Margarita Zayas

7

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Margarita Zayas Lopez

Creative Commons Attribution 4.0 International

8

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language of work or name

1 reference

August 2009

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published in

PLOS Pathogens

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volume

5

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issue

8

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page(s)

e1000546

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copyright license

start time

14 August 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

20 March 2017

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Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

20 March 2017

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Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase

20 March 2017

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Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

20 March 2017

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Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro

20 March 2017

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Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

20 March 2017

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Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

20 March 2017

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Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

20 March 2017

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Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

20 March 2017

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Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious Virus

20 March 2017

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Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras

20 March 2017

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Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes

20 March 2017

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NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

20 March 2017

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Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses

20 March 2017

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Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

20 March 2017

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20 March 2017

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Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

20 March 2017

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The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

20 March 2017

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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

20 March 2017

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Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

20 March 2017

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Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

20 March 2017

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Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid

20 March 2017

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Kinetic and structural analyses of hepatitis C virus polyprotein processing

20 March 2017

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Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

20 March 2017

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Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation

20 March 2017

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Replication of hepatitis C virus

20 March 2017

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Complete replication of hepatitis C virus in cell culture

20 March 2017

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

20 March 2017

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The lipid droplet is an important organelle for hepatitis C virus production

20 March 2017

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

20 March 2017

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Novel insights into hepatitis C virus replication and persistence

20 March 2017

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The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

7 April 2017

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7 April 2017

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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

21 January 2018

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Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication

7 April 2017

1 reference

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The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly

9 May 2017

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Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy

29 September 2017

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Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus.

29 September 2017

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Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

29 September 2017

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The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

29 September 2017

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From structure to function: new insights into hepatitis C virus RNA replication

29 September 2017

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Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins

29 September 2017

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Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2718831

Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication

29 September 2017

1 reference

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Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.

29 September 2017

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Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride

29 September 2017

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29 September 2017

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Specific inhibition of hepatitis C virus replication by cyclosporin A.

29 September 2017

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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

29 September 2017

1 reference

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Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity

29 September 2017

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Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

29 September 2017

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Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.

29 September 2017

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Biological effects of cyclosporin A: a new antilymphocytic agent. 1976.

2 June 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000546

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1000546

10.1371/JOURNAL.PPAT.1000546

21 January 2018

Identifiers

DOI

1 reference

2143471

2143471

1 reference

1 reference

1 reference