Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 YHR164C (Q27547670)

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fungal protein found in Saccharomyces cerevisiae S288c

YHR164C
bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2
DNA2

Language	Label	Description	Also known as
English	Bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 YHR164C	fungal protein found in Saccharomyces cerevisiae S288c	YHR164C bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 DNA2

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P38859

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P38859

DNA replication factor Dna2, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

catalytic activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

helicase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

single-stranded DNA endodeoxyribonuclease activity

determination method

DNA helicase activity

determination method

1 reference

9 May 2019

A yeast gene required for DNA replication encodes a protein with homology to DNA helicases

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

iron-sulfur cluster binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

protein binding

determination method

4 references

9 May 2019

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

5'-3' DNA helicase activity

determination method

1 reference

9 May 2019

Dna2 exhibits a unique strand end-dependent helicase function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

5'-flap endonuclease activity

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

determination method

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

27 February 2018

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

27 February 2018

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

determination method

1 reference

27 February 2018

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

site of double-strand break

determination method

1 reference

9 May 2019

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

determination method

4 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

10 September 2018

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

10 September 2018

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P38859&geneProductId=UniProtKB:P38859

determination method

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

biological process

lagging strand elongation

determination method

2 references

9 May 2019

Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

meiotic DNA double-strand break processing

determination method

1 reference

9 May 2019

Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

DNA replication

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

DNA-dependent DNA replication

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

telomere maintenance

determination method

1 reference

9 May 2019

Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

DNA double-strand break processing

determination method

3 references

9 May 2019

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

9 May 2019

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

DNA duplex unwinding

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

nucleic acid phosphodiester bond hydrolysis

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

DNA replication, Okazaki fragment processing

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

replication fork reversal

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38859

determination method

DNA replication factor Dna2, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P38859

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Saccharomyces Genome Database ID

1 reference

20 March 2022

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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