New structural motifs on the chymotrypsin fold and their potential roles in complement factor B (Q27620995)

1

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Y Xu

2

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M Carson

3

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D Moore

4

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K J Macon

5

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J E Volanakis

6

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S V Narayana

Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D

7

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language of work or name

English

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publication date

17 January 2000

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published in

The EMBO Journal

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volume

19

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page(s)

164-73

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issue

2

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cites work

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Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity

20 March 2017

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Crystal structure of the catalytic domain of human plasmin complexed with streptokinase

20 March 2017

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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

20 March 2017

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Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

20 March 2017

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Complement factor D, a novel serine protease

20 March 2017

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Two conformations of the integrin A-domain (I-domain): a pathway for activation?

20 March 2017

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Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion

20 March 2017

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

20 March 2017

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Relocating a negative charge in the binding pocket of trypsin

20 March 2017

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Errors in protein structures

20 March 2017

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Principles of protein-protein interactions

20 March 2017

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Comparative protein modelling by satisfaction of spatial restraints

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

20 March 2017

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Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates

20 March 2017

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Serine Proteases: Structure and Mechanism of Catalysis

20 March 2017

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The human complement system: assembly of the classical pathway C3 convertase

20 March 2017

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20 March 2017

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Checking your imagination: applications of the free R value

7 April 2017

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Structural basis of substrate specificity in the serine proteases

7 April 2017

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Efficient rebuilding of protein structures.

7 April 2017

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Structural and energetic determinants of the S1-site specificity in serine proteases

29 September 2017

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Not your average density.

29 September 2017

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Analysis of the short consensus repeats of human complement factor B by site-directed mutagenesis

29 September 2017

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C3 convertases of complement. Molecular genetics, structure and function of the catalytic domains, C2 and B.

29 September 2017

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Site-directed mutagenesis of the region around Cys-241 of complement component C2. Evidence for a C4b binding site.

29 September 2017

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Natural protein proteinase inhibitors and their interaction with proteinases

29 September 2017

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The atypical serine proteases of the complement system.

29 September 2017

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Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity.

2 June 2018

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MHC Class III products: an electron microscopic study of the C3 convertases of human complement

2 June 2018

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The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinase

2 June 2018

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Probing functional sites on complement protein B with monoclonal antibodies. Evidence for C3b-binding sites on Ba.

2 June 2018

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"Soft docking": matching of molecular surface cubes

2 June 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

2 June 2018

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The integrin I domain: crystals, metals and related artefacts.

21 January 2018

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AMoRe: an automated package for molecular replacement

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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Improved Fourier coefficients for maps using phases from partial structures with errors

21 January 2018

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The compact five-domain structure of factor B of human complement by X-ray and neutron solution scattering and homology modelling

21 January 2018

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Surface Loops Adjacent to the Cation-Binding Site of the Complement Factor B von Willebrand Factor Type A Module Determine C3b Binding Specificity†

21 January 2018

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Model building and refinement practice

21 January 2018

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Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding

27 November 2018

1 reference

12 December 2020

Proteolytic activity of the different fragments of factor B on the third component of complement (C3). Involvement of the N-terminal domain of Bb in magnesium binding

1 reference

12 December 2020

Residual hemolytic and proteolytic activity expressed by Bb after decay-dissociation of C3b,Bb

1 reference

12 December 2020

Studies on esterolytic activity of alternative complement component factor B

1 reference

12 December 2020

Ultrastructure of cobra venom factor-dependent C3/C5 convertase and its zymogen, factor B of human complement

1 reference

12 December 2020

Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C

1 reference

12 December 2020