The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations (Q27649316)

7

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Kenneth W. Kinzler

6

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L. Mario Amzel

9

0 references

Victor Velculescu

5

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Chuan-Hsiang Huang

Chuan-Hsiang Huang

1

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Sandra B. Gabelli

Sandra B Gabelli

8

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Yardena Samuels

Yardena Samuels

4

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Diana Mandelker

2

Diana Mandelker

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Oleg Schmidt-Kittler

3

Signaling by distinct classes of phosphoinositide 3-kinases

Oleg Schmidt-Kittler

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language of work or name

English

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publication date

14 December 2007

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published in

Science

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volume

318

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issue

5857

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page(s)

1744-8

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cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

The phosphoinositide 3-kinase pathway

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Regulation of cell death protease caspase-9 by phosphorylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

The biology and clinical relevance of the PTEN tumor suppressor pathway

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

High frequency of mutations of the PIK3CA gene in human cancers

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1150799

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Oncogenic PI3K deregulates transcription and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Cancer-specific mutations in phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Functional analysis of PIK3CA gene mutations in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Cancer-specific mutations in PIK3CA are oncogenic in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Rare cancer-specific mutations in PIK3CA show gain of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Chemically targeting the PI3K family

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799

Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1150799