Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology (Q27655733)

10

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Natacha Rochel

9

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Diana Ivanova

object named as

Diana Ivanova

5

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Hinrich Gronemeyer

object named as

Hinrich Gronemeyer

11

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Reinhold Tacke

12

object named as

Reinhold Tacke

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author name string

W Peter Lippert

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Christian Burschka

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Kathrin Götz

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Martin Kaupp

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Claudine Gaudon

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Yoshiteru Sato

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Pierre Antony

Chemistry challenges in lead optimization: silicon isosteres in drug discovery

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language of work or name

1 reference

July 2009

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published in

ChemMedChem

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volume

4

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issue

7

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page(s)

1143-52

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cites work

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Exploitation of silicon medicinal chemistry in drug discovery

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Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

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(R)-sila-venlafaxine: a selective noradrenaline reuptake inhibitor for the treatment of emesis

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Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology

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Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate

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Action of (R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret.

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Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues

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Structural analysis of silanediols as transition-state-analogue inhibitors of the benchmark metalloprotease thermolysin

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Photodynamic therapy with the phthalocyanine photosensitizer Pc 4: the case experience with preclinical mechanistic and early clinical-translational studies

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Retinoids selective for retinoid X receptor response pathways

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Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity

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Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

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Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction.

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RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

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Molecular recognition of agonist ligands by RXRs

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Retinoic acid receptor alpha and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death.

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Retinoids regulate survival and antigen presentation by immature dendritic cells

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Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.

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Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

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Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

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Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells

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Density-functional approximation for the correlation energy of the inhomogeneous electron gas

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Self‐consistent molecular orbital methods. XX. A basis set for correlated wave functions

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Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

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Design of selective nuclear receptor modulators: RAR and RXR as a case study

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The promise of retinoids to fight against cancer.

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The Rexinoid LG100268 prevents the development of preinvasive and invasive estrogen receptor negative tumors in MMTV-erbB2 mice

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A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland

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RAR and RXR modulation in cancer and metabolic disease

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Phase annealing in SHELX-90: direct methods for larger structures

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Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex

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Detection, delineation, measurement and display of cavities in macromolecular structures

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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