RAR and RXR modulation in cancer and metabolic disease (Q36956230)

17 August 2017

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title

RAR and RXR modulation in cancer and metabolic disease (English)

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17 August 2017

Hinrich Gronemeyer

5

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Lucia Altucci

object named as

Lucia Altucci

1

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Angel R de Lera

object named as

Angel R de Lera

4

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author name string

Mark D Leibowitz

2

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17 August 2017

Kathleen M Ogilvie

3

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17 August 2017

publication date

1 October 2007

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Nature Reviews Drug Discovery

17 August 2017

published in

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17 August 2017

volume

6

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17 August 2017

issue

10

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17 August 2017

page(s)

793-810

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Principles for modulation of the nuclear receptor superfamily

17 August 2017

cites work

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Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

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RXR is an essential component of the oncogenic PML/RARA complex in vivo

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A sumoylation site in PML/RARA is essential for leukemic transformation.

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PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

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Cytoplasmic PML function in TGF-beta signalling

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PML is a direct p53 target that modulates p53 effector functions

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PML regulates p53 stability by sequestering Mdm2 to the nucleolus

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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

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Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

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Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL

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SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

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Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer.

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Methylation and silencing of the retinoic acid receptor-beta 2 gene in cervical cancer

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Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung

31 March 2020

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The targeted disruption of both alleles of RARbeta(2) in F9 cells results in the loss of retinoic acid-associated growth arrest.

31 March 2020

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Rational design of RAR-selective ligands revealed by RARbeta crystal structure

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Retinoic acid determines life span of leukemic cells by inducing antagonistic apoptosis-regulatory programs

31 March 2020

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IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo

31 March 2020

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IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo

31 March 2020

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Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer

31 March 2020

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Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk.

31 March 2020

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Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity.

31 March 2020

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Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil

31 March 2020

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Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy

31 March 2020

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Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

31 March 2020

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Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

31 March 2020

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

31 March 2020

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

31 March 2020

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Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis

31 March 2020

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Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

31 March 2020

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A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function

31 March 2020

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All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia

31 March 2020

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p53 upregulates death receptor 4 expression through an intronic p53 binding site

31 March 2020

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Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.

31 March 2020

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Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

31 March 2020

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Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation

31 March 2020

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An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium.

31 March 2020

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Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

31 March 2020

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Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma

31 March 2020

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v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

31 March 2020

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Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid

31 March 2020

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RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.

31 March 2020

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Molecular basis of sun-induced premature skin ageing and retinoid antagonism.

31 March 2020

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Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment.

31 March 2020

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The promise of retinoids to fight against cancer.

31 March 2020

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Retinoic acid receptors and cancers.

31 March 2020

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Chemoprevention of hepatocellular carcinoma: use of tamoxifen in an animal model of hepatocarcinogenesis

31 March 2020

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Activity of interferon-alpha and isotretinoin in patients with advanced, refractory lymphoid malignancies

31 March 2020

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Randomized phase II/III trial of interferon Alfa-2a with and without 13-cis-retinoic acid in patients with progressive metastatic renal cell Carcinoma: the European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Group

31 March 2020

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9-cis-retinoic acid capsules in the treatment of AIDS-related Kaposi sarcoma: results of a phase 2 multicenter clinical trial

31 March 2020

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Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors

31 March 2020

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Targeting Nur77 translocation

31 March 2020

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Fenretinide and risk reduction of second breast cancer

31 March 2020

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Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis

31 March 2020

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A novel atypical retinoid endowed with proapoptotic and antitumor activity

31 March 2020

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Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

31 March 2020

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Topical and systemic retinoid therapy for cutaneous T-cell lymphoma

31 March 2020

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Retinoids: therapeutic applications and mechanisms of action in cutaneous T-cell lymphoma

31 March 2020

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The addition of interferon gamma to oral bexarotene therapy with photopheresis for Sézary syndrome

31 March 2020

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A phase II multicenter clinical trial of systemic bexarotene in psoriasis

31 March 2020

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Phase II trial of the novel retinoid, bexarotene, and gemcitabine plus carboplatin in advanced non-small-cell lung cancer

31 March 2020

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Bexarotene in combination with chemotherapy fails to prolong survival in patients with advanced non-small-cell lung cancer: results from the SPIRIT I and II trials

31 March 2020

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31 March 2020

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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.

31 March 2020

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Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid

31 March 2020

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Oral cancer prevention and the evolution of molecular-targeted drug development

31 March 2020

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Retinoids in cancer chemoprevention

31 March 2020

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Progress in chemoprevention of breast cancer

31 March 2020

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Breast cancer prevention trials using retinoids

31 March 2020

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Therapeutic applications for ligands of retinoid receptors

31 March 2020

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Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation

31 March 2020

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Preliminary observations on the use of topical tazarotene to treat basal-cell carcinoma.

31 March 2020

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Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia

31 March 2020

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RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

31 March 2020

1 reference

Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation

31 March 2020

1 reference

Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways.

31 March 2020

1 reference

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

31 March 2020

1 reference

Retinoid-interferon therapy of solid tumors

31 March 2020

1 reference

The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression

31 March 2020

1 reference

Antiproliferative effects of retinoic acid/interferon in cervical carcinoma cell lines: cooperative growth suppression of IRF-1 and p53

31 March 2020

1 reference

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

31 March 2020

1 reference

Epigenetics in human disease and prospects for epigenetic therapy

31 March 2020

1 reference

The history of cancer epigenetics

31 March 2020

1 reference

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

31 March 2020

1 reference

Histone deacetylases and cancer: causes and therapies

31 March 2020

1 reference

Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

31 March 2020

1 reference

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells.

31 March 2020

1 reference

Acute myeloid leukemia: therapeutic impact of epigenetic drugs

31 March 2020

1 reference

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

31 March 2020

1 reference

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

31 March 2020

1 reference

MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

31 March 2020

1 reference

hDOT1L links histone methylation to leukemogenesis

31 March 2020

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

31 March 2020

1 reference

The polycomb group protein EZH2 is involved in progression of prostate cancer

31 March 2020

1 reference

Retinoid x receptor heterodimers in the metabolic syndrome

31 March 2020

1 reference

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

31 March 2020

1 reference

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies

31 March 2020

1 reference

The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

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Structure-based design of potent retinoid X receptor alpha agonists

31 March 2020

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Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors

31 March 2020

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Activation of the Retinoid X Receptor Suppresses Appetite in the Rat

31 March 2020

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Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.

31 March 2020

1 reference

Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target

31 March 2020

1 reference

Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice

31 March 2020

1 reference

Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes

31 March 2020

1 reference

Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes

31 March 2020

1 reference

Retinoid X receptor gamma-deficient mice have increased skeletal muscle lipoprotein lipase activity and less weight gain when fed a high-fat diet.

31 March 2020

1 reference

Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse

31 March 2020

1 reference

Temporal changes in gene expression in the arcuate nucleus precede seasonal responses in adiposity and reproduction

31 March 2020

1 reference

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

31 March 2020

1 reference

A retinoid X receptor antagonist, HX531, improves leptin resistance without increasing plasma leptin level in KK-Ay mice under normal dietary conditions

31 March 2020

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Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity.

31 March 2020

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The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor gamma ligands

31 March 2020

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A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice

31 March 2020

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Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids

31 March 2020

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Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

31 March 2020

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Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group

31 March 2020

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Arsenic trioxide, a therapeutic agent for APL.

31 March 2020

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The molecular biology of acute promyelocytic leukemia

31 March 2020

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Topical treatment of basal cell carcinoma with tazarotene: a clinicopathological study on a large series of cases

31 March 2020

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Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

31 March 2020

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Synthesis and biological activity of retinoic acid receptor-alpha specific amides

31 March 2020

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Identification of highly potent retinoic acid receptor alpha-selective antagonists

31 March 2020

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Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes

31 March 2020

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Structural basis for isotype selectivity of the human retinoic acid nuclear receptor

31 March 2020

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Conformational adaptation of agonists to the human nuclear receptor RAR gamma

31 March 2020

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Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma

31 March 2020

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Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes

31 March 2020

1 reference

Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells

31 March 2020

1 reference

4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists

31 March 2020

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Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

31 March 2020

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Activation of c-Raf kinase by ultraviolet light. Regulation by retinoids

31 March 2020

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Retro-retinoids in regulated cell growth and death

31 March 2020

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Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology

31 March 2020

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Novel retinoic acid derivative ABPN has potent inhibitory activity on cell growth and apoptosis in cancer cells

31 March 2020

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Anti-proliferative effects of the arotinoid Ro 40-8757 on human cancer cell lines in vitro

31 March 2020

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Programmed cell death (PCD) associated with the stilbene motif of arotinoids: discovery of novel apoptosis inducer agents possessing activity on multidrug resistant tumor cells.

31 March 2020

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31 March 2020

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Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.

31 March 2020

1 reference

Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest

31 March 2020

1 reference

Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2397

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17 August 2017

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