Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2 (Q27657133)

3

Sarah

L'Heureux

1 reference

19 October 2023

Todd Ashworth

4

Todd

Ashworth

1 reference

19 October 2023

Michael J Malecki

5

Michael J

Malecki

1 reference

19 October 2023

Cheryll Sanchez-Irizarry

6

Cheryll

Sanchez-Irizarry

1 reference

19 October 2023

Debbie G McArthur

7

Debbie G

McArthur

1 reference

19 October 2023

Gavin Histen

8

Gavin

Histen

1 reference

19 October 2023

Jennifer L Mitchell

9

Jennifer L

Mitchell

1 reference

19 October 2023

Jon C Aster

10

Jon C

Aster

1 reference

19 October 2023

Stephen C Blacklow

11

Stephen C

Creative Commons Attribution 4.0 International

Blacklow

1 reference

19 October 2023

language of work or name

English

0 references

publication date

24 August 2009

0 references

published in

PLOS One

0 references

volume

4

0 references

page(s)

e6613

0 references

issue

8

0 references

copyright license

start time

24 August 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Structural basis for autoinhibition of Notch

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

The Notch1 receptor is cleaved constitutively by a furin-like convertase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Using NMRView to visualize and analyze the NMR spectra of macromolecules

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Presenilin is required for activity and nuclear access of Notch in Drosophila

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Furin cleavage is not a requirement for Drosophila Notch function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Calcium depletion dissociates and activates heterodimeric notch receptors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Notch signalling: a simple pathway becomes complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Notch signaling in leukemia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Ligand-induced signaling in the absence of furin processing of Notch1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Nuclear Notch1 signaling and the regulation of dendritic development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Mutation at the processing site of chicken low density lipoprotein receptor-related protein impairs efficient endoplasmic reticulum exit, but proteolytic cleavage is not essential for its endocytic functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

Regions of Drosophila Notch that contribute to ligand binding and the modulatory influence of Fringe.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006613

High-level bacterial expression and 15N-alanine-labeling of bovine trypsin. Application to the study of trypsin-inhibitor complexes and trypsinogen activation by NMR spectroscopy

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006613

Structural requirements for notch signalling with delta and serrate during the development and patterning of the wing disc of Drosophila.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726630

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19701457

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanism of membrane fusion by viral envelope proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19701457

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19701457

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0006613

1 reference

1440144

ADS bibcode

2009PLoSO...4.6613G

0 references

1440144

1 reference

1 reference

1 reference