An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase (Q27662837)

1

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Xiaojing Tang

2

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Victor Neduva

3

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Nadine Elowe

4

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Eric D Brown

5

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Mike Tyers

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

7

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publication date

July 2010

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published in

Nature Biotechnology

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volume

28

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issue

7

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page(s)

733-7

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cites work

1 reference

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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

20 March 2017

1 reference

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Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

20 March 2017

1 reference

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Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell

20 March 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

20 March 2017

1 reference

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

20 March 2017

1 reference

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Phosducin induces a structural change in transducin beta gamma

20 March 2017

1 reference

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Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis

20 March 2017

1 reference

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

20 March 2017

1 reference

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TOR signaling in growth and metabolism

20 March 2017

1 reference

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20 March 2017

1 reference

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Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Function and regulation of cullin-RING ubiquitin ligases

20 March 2017

1 reference

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

20 March 2017

1 reference

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The WD repeat: a common architecture for diverse functions

20 March 2017

1 reference

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Structural diversity of G protein-coupled receptors and significance for drug discovery

20 March 2017

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

7 April 2017

1 reference

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A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin

7 April 2017

1 reference

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Evolutionarily conserved networks of residues mediate allosteric communication in proteins

7 April 2017

1 reference

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Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Identification of SCF ubiquitin ligase substrates by global protein stability profiling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Drug discovery in the ubiquitin-proteasome system.

29 September 2017

1 reference

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BINOL: a versatile chiral reagent

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Inducible dissociation of SCF(Met30) ubiquitin ligase mediates a rapid transcriptional response to cadmium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Inactivation of hCDC4 can cause chromosomal instability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Beta propellers: structural rigidity and functional diversity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

Allosteric Modulation of G Protein–Coupled Receptors

29 September 2017

1 reference

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Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445864

27 November 2018

Prolyl Oligopeptidase

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Crystallographic refinement of ligand complexes

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Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms

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InterProScan--an integration platform for the signature-recognition methods in InterPro

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The Universal Protein Resource (UniProt) in 2010

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Maximum discrimination hidden Markov models of sequence consensus

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ProbCons: Probabilistic consistency-based multiple sequence alignment

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