HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism (Q27675409)

2

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Taejin Yoon

3

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Corrie A Painter

4

0 references

Wei Jiang

5

0 references

Elizabeth D Mellins

6

0 references

Lawrence J Stern

Nature Structural & Molecular Biology

7

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publication date

January 2013

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published in

0 references

volume

20

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issue

1

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page(s)

90-8

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cites work

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DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression

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HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

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Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides

20 March 2017

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Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice

20 March 2017

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Altered antigen presentation in mice lacking H2-O

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Negative regulation by HLA-DO of MHC class II-restricted antigen processing

20 March 2017

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HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH

20 March 2017

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Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

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Cutting edge: HLA-DO impairs the incorporation of HLA-DM into exosomes

20 March 2017

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HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide

29 September 2017

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DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms

29 September 2017

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Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence

29 September 2017

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Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond

29 September 2017

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Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes

29 September 2017

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HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available

29 September 2017

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29 September 2017

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HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.

29 September 2017

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Right place, right time, right peptide: DO keeps DM focused

29 September 2017

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A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM.

29 September 2017

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Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

29 September 2017

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Germinal center B cells regulate their capability to present antigen by modulation of HLA-DO.

29 September 2017

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Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development

29 September 2017

1 reference

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The kinetic basis of peptide exchange catalysis by HLA-DM

29 September 2017

1 reference

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Prolonged antigen persistence within nonterminal late endocytic compartments of antigen-specific B lymphocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Determination of the HLA-DM interaction site on HLA-DR molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Conserved structural features between HLA-DO beta and -DR beta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Mediation by HLA-DM of dissociation of peptides from HLA-DR

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

A novel class II MHC molecule with unusual tissue distribution

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

17 The kinetics of reversible tight-binding inhibition

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3537886

Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO.

2 June 2018

1 reference

Nomenclature for factors of the HLA system, 2010

21 January 2018

1 reference

Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro.

21 January 2018

1 reference

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

T-cell apoptosis and differential human leucocyte antigen class II expression in human thymus

21 January 2018

1 reference

Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation

21 January 2018

1 reference

H2-O expression in primary dendritic cells

31 March 2020

1 reference

Analysis of H2-O influence on antigen presentation by B cells

31 March 2020

1 reference

H2-O influence on antigen presentation in H2-E-expressing mice

31 March 2020

1 reference

Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation

31 March 2020

1 reference

Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body

31 March 2020

1 reference

Global indicators of X-ray data quality

31 March 2020

1 reference

A three-step kinetic mechanism for peptide binding to MHC class II proteins

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2460

1 reference

Dimensions Publication ID

1017924374

0 references

Fatcat ID

release_dukhzlufwffxznxoryc4zyvhby

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dukhzlufwffxznxoryc4zyvhby

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

1 reference

PubMed publication ID

23222639

1 reference