Small molecule induced reactivation of mutant p53 in cancer cells (Q27677872)

3

object named as

Andreas C Joerger

0 references

Rainer Wilcken

object named as

Rainer Wilcken

2

0 references

John Spencer

object named as

John Spencer

6

0 references

author name string

Xiangrui Liu

1

0 references

Irina S Chuckowree

4

0 references

Jahangir Amin

Creative Commons Attribution 3.0 Unported

5

0 references

language of work or name

English

0 references

publication date

July 2013

0 references

published in

Nucleic Acids Research

0 references

volume

41

0 references

issue

12

0 references

page(s)

6034-44

0 references

copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

20 March 2017

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Non-oxime pyrazole based inhibitors of B-Raf kinase

20 March 2017

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Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

20 March 2017

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

20 March 2017

1 reference

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

20 March 2017

1 reference

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Thermodynamic stability of wild-type and mutant p53 core domain

20 March 2017

1 reference

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Movement of Bax from the cytosol to mitochondria during apoptosis

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

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20 March 2017

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PHENIX: building new software for automated crystallographic structure determination

20 March 2017

2 references

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20 March 2017

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Integration of macromolecular diffraction data

21 January 2018

1 reference

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

20 March 2017

1 reference

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

20 March 2017

1 reference

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Blinded by the Light: The Growing Complexity of p53

20 March 2017

1 reference

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The biochemistry of apoptosis

7 April 2017

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

7 April 2017

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Cancer. p53, guardian of the genome

7 April 2017

1 reference

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Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

7 April 2017

1 reference

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First-order rate-determining aggregation mechanism of p53 and its implications

29 September 2017

1 reference

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Allele-specific p53 mutant reactivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs

29 September 2017

1 reference

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CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

29 September 2017

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Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

29 September 2017

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Microwave-mediated synthesis of an arylboronate library

29 September 2017

1 reference

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Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells

29 September 2017

1 reference

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The tumor suppressor p53: from structures to drug discovery

29 September 2017

1 reference

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Awakening guardian angels: drugging the p53 pathway

29 September 2017

1 reference

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Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

29 September 2017

1 reference

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Transcription-independent p53 apoptosis: an alternative route to death

29 September 2017

1 reference

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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Cytoplasmic functions of the tumour suppressor p53.

29 September 2017

1 reference

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Structural biology of the tumor suppressor p53.

29 September 2017

1 reference

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Structure-function-rescue: the diverse nature of common p53 cancer mutants

29 September 2017

1 reference

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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

29 September 2017

1 reference

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Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Regulation of the G2/M transition by p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695503

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKT305

Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKT305

Pharmacological rescue of mutant p53 conformation and function

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutations in p53 produce a common conformational effect that can be detected with a panel of monoclonal antibodies directed toward the central part of the p53 protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKT305

1 reference

1515149

1515149

1 reference

1 reference

1 reference