Structure-function-rescue: the diverse nature of common p53 cancer mutants (Q36777367)

16 August 2017

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title

Structure-function-rescue: the diverse nature of common p53 cancer mutants (English)

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16 August 2017

A C Joerger

1

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PubMed ID

17401432

16 August 2017

A R Fersht

series ordinal

2

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PubMed ID

17401432

16 August 2017

language of work or name

English

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publication date

1 April 2007

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16 August 2017

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16 August 2017

26

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16 August 2017

15

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16 August 2017

2226-2242

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210291

16 August 2017

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cites work

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

A global suppressor motif for p53 cancer mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

p53 contains large unstructured regions in its native state

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Post-translational modification of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Some p53-binding proteins that can function as arbiters of life and death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structural analysis of mutations in the hydrophobic cores of barnase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Analysis of JNK, Mdm2 and p14(ARF) contribution to the regulation of mutant p53 stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Kinetic partitioning during folding of the p53 DNA binding domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Small molecules that reactivate mutant p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Solution structure of p53 core domain: structural basis for its instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

How many mutant p53 molecules are needed to inactivate a tetramer?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The role of tetramerization in p53 function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Analysing the ability to retain sidechain hydrogen-bonds in mutant proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Analysis of void volumes in proteins and application to stability of the p53 tumour suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The N-terminal domain of p53 is natively unfolded.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Cooperative binding of p53 to DNA: regulation by protein-protein interactions through a double salt bridge

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Effect of Zn2+on DNA Recognition and Stability of the p53 DNA-Binding Domain†

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Modulation of binding of DNA to the C-terminal domain of p53 by acetylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Kinetic Instability of p53 Core Domain Mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

p300/CBP/p53 interaction and regulation of the p53 response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The UMD TP53 database and website: update and revisions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Mechanisms of Suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure of the p53 core domain dimer bound to DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural basis of DNA recognition by p53 tetramers.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Genetics of hepatocellular tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The complexity of p53 stabilization and activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

A nucleotide substitution model with nearest-neighbour interactions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Predicting the transactivation activity of p53 missense mutants using a four-body potential score derived from Delaunay tessellations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

In vitro evolution of thermostable p53 variants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The IARC TP53 database: new online mutation analysis and recommendations to users

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

In the quest for stable rescuing mutants of p53: computational mutagenesis of flexible loop L1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Comparison of the human and worm p53 structures suggests a way for enhancing stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The coupon collector and the suppressor mutation: estimating the number of compensatory mutations by maximum likelihood.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Recognition of DNA by p53 Core Domain and Location of Intermolecular Contacts of Cooperative Binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure of the negative regulatory domain of p53 bound to S100B(betabeta)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Effect of phosphorylation on tetramerization of the tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Increased apoptosis induction by 121F mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The folding of an enzyme. II. Substructure of barnase and the contribution of different interactions to protein stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Mutant conformation of p53. Precise epitope mapping using a filamentous phage epitope library

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Functional complementation between mutations at two distant positions in Escherichia coli RNA polymerase as revealed by second-site suppression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

ASPP [corrected] and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Core domain interactions in full-length p53 in solution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The 'wildtype' conformation of p53: epitope mapping using hybrid proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Regulation of DNA binding of p53 by its C-terminal domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Cooperative binding of tetrameric p53 to DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Comparative binding of p53 to its promoter and DNA recognition elements.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Strategies for therapeutic targeting of the p53 pathway in cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Structural assessment of single amino acid mutations: application to TP53 function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

A temperature-sensitive mutant of human p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Mutational analysis of the p53 core domain L1 loop.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210291

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210291

1 reference

16 August 2017

1 reference

PubMed ID

17401432